School of Nutrition, Chung Shan Medical University, Taichung, Taiwan.
Nutrition. 2012 Mar;28(3):250-5. doi: 10.1016/j.nut.2011.06.004. Epub 2011 Oct 12.
The purpose of this study was to investigate the effect of coenzyme Q10 supplementation on oxidative stress and antioxidant enzyme activity in patients with coronary artery disease (CAD).
This was an intervention study. Patients who were identified by cardiac catheterization as having at least 50% stenosis of one major coronary artery or receiving percutaneous transluminal coronary angioplasty (n = 51) were randomly assigned to the placebo group (n = 14) or one of the two coenzyme Q10-supplemented groups (60 mg/d, n = 19 [Q10-60 group]; 150 mg/d, n = 18 [Q10-150 group]). Intervention was administered for 12 wk. Patients' blood samples were analyzed every 4 wk for plasma coenzyme Q10 concentrations, malondialdehyde (MDA), and antioxidant enzyme (catalase [CAT], superoxide dismutase [SOD], glutathione peroxidase) activity.
Forty-three subjects with CAD completed intervention study. Plasma coenzyme Q10 concentration increased significantly after coenzyme the Q10-150 intervention (P < 0.01). The MDA levels were significantly lower than baseline in the Q10-150 group at week 4 (P = 0.03). The Q10-150 group had significantly lower MDA levels than the placebo group at week 8 (P = 0.03). With respect to antioxidant enzyme activity, subjects in the Q10-150 group had significantly higher CAT (P = 0.03) and SOD (P = 0.03) activity than the placebo group at week 12. The plasma coenzyme Q10 concentration was significantly correlated with MDA levels (r = -0.35, P = 0.02) and CAT (r = 0.43, P = 0.01) and SOD activity (r = 0.39, P = 0.01). The ratio of plasma coenzyme Q10 to total cholesterol was significantly correlated with SOD activity (r = 0.39, P = 0.02). The ratio of plasma coenzyme Q10 to low-density lipoprotein was significantly correlated with CAT (r = 0.35, P = 0.04) and SOD (r = 0.45, P = 0.01) activity. However, there was no relation between coenzyme Q10 concentration and glutathione peroxidase activity.
Coenzyme Q10 supplements at a dose of 150 mg can decrease oxidative stress and increase antioxidant enzyme activity in patients with CAD. A higher dose of coenzyme Q10 supplements (>150 mg/d) might promote rapid and sustainable antioxidation in patients with CAD.
本研究旨在探讨辅酶 Q10 补充对冠心病（CAD）患者氧化应激和抗氧化酶活性的影响。
这是一项干预研究。通过心脏导管检查确定至少有一条主要冠状动脉狭窄 50%或接受经皮腔内冠状动脉成形术（PTCA）的患者（n=51）被随机分配至安慰剂组（n=14）或辅酶 Q10 补充组（60 mg/d，n=19[Q10-60 组]；150 mg/d，n=18[Q10-150 组]）。干预持续 12 周。每 4 周检测一次患者的血液样本，以分析血浆辅酶 Q10 浓度、丙二醛（MDA）和抗氧化酶（过氧化氢酶[CAT]、超氧化物歧化酶[SOD]、谷胱甘肽过氧化物酶）活性。
43 例 CAD 患者完成了干预研究。辅酶 Q10-150 干预后，血浆辅酶 Q10 浓度显著升高（P<0.01）。Q10-150 组在第 4 周时 MDA 水平明显低于基线（P=0.03）。第 8 周时，Q10-150 组的 MDA 水平明显低于安慰剂组（P=0.03）。在抗氧化酶活性方面，Q10-150 组在第 12 周时 CAT（P=0.03）和 SOD（P=0.03）活性明显高于安慰剂组。血浆辅酶 Q10 浓度与 MDA 水平（r=-0.35，P=0.02）和 CAT（r=0.43，P=0.01）和 SOD 活性（r=0.39，P=0.01）显著相关。血浆辅酶 Q10 与总胆固醇的比值与 SOD 活性（r=0.39，P=0.02）显著相关。血浆辅酶 Q10 与低密度脂蛋白的比值与 CAT（r=0.35，P=0.04）和 SOD（r=0.45，P=0.01）活性显著相关。然而，辅酶 Q10 浓度与谷胱甘肽过氧化物酶活性之间没有关系。
辅酶 Q10 补充剂剂量为 150 mg 可降低 CAD 患者的氧化应激并增加抗氧化酶活性。较高剂量的辅酶 Q10 补充剂（>150 mg/d）可能会促进 CAD 患者的快速和持续抗氧化作用。
