The University of Melbourne, Department of Physiotherapy, Australia.
J Sci Med Sport. 2012 Mar;15(2):102-9. doi: 10.1016/j.jsams.2011.08.007. Epub 2011 Oct 12.
This study aimed to determine the efficacy of an exercise program for post-menopausal women with osteopenia undertaken in community exercise facilities.
Randomised, single-blind controlled trial.
Thirty-nine community volunteers with hip osteopenia and not taking bone-enhancing medication were randomly allocated to an exercise (EX) or control (CON) group. EX participants attended an exercise facility in Melbourne, Australia, three times/week for 52 weeks (with a 2 week break) for partially supervised exercises targeting hip bone strength, muscle strength and balance. They also performed daily jumping exercises at home. CON participants continued with their usual care. All participants were given calcium supplementation. Assessment at baseline and 52 weeks measured bone mineral density (BMD) at the proximal femur and lumbar spine. Health-related quality of life (QOL) and objective measures of strength and balance were also collected.
ANCOVA adjusting for baseline values revealed a small benefit of exercise in mean total hip BMD (the primary outcome) with a significant mean difference in change between groups of -0.012 g/cm(2) (95% CI -0.022 to -0.002 g/cm(2)). EX participants improved 0.5% compared with a 0.9% loss for CON participants. The only other between-group differences were in QOL and a test of trunk and upper limb endurance, which both favoured the EX group.
This exercise program appears to have modest benefits for post-menopausal women with osteopenia who are not taking bone-enhancing medication. This mode of exercise delivery has adherence and progression limitations but may be appropriate to recommend for some people.
本研究旨在确定在社区运动设施中进行的针对骨质疏松症绝经后妇女的运动方案的疗效。
随机、单盲对照试验。
39 名髋部骨质疏松症且未服用骨增强药物的社区志愿者被随机分配到运动（EX）或对照组（CON）。EX 参与者在澳大利亚墨尔本的一个运动设施中每周进行三次，为期 52 周（有两周休息期），接受针对髋骨强度、肌肉力量和平衡的部分监督运动。他们还在家中进行日常跳跃运动。CON 参与者继续接受常规护理。所有参与者均给予钙补充剂。基线和 52 周时的评估测量了股骨近端和腰椎的骨矿物质密度（BMD）。还收集了与健康相关的生活质量（QOL）和力量及平衡的客观测量值。
调整基线值的协方差分析显示，运动对总髋部 BMD 有较小的益处（主要结局），组间变化的平均差异为 -0.012 g/cm(2)（95%置信区间 -0.022 至 -0.002 g/cm(2)）。EX 参与者的改善幅度为 0.5%，而 CON 参与者的损失幅度为 0.9%。唯一的其他组间差异在于 QOL 和躯干和上肢耐力测试，EX 组均表现出优势。
对于不服用骨增强药物的骨质疏松症绝经后妇女，这种运动方案似乎有适度的益处。这种运动方式的实施存在依从性和进展限制，但可能适合推荐给某些人。
