Department of Neurological Surgery, University of California, Davis, CA, United States.
Epilepsy Res. 2012 Feb;98(2-3):264-8. doi: 10.1016/j.eplepsyres.2011.09.016. Epub 2011 Oct 12.
We investigated the role of aquaporin-4 in the development of cerebral edema following kainic acid-induced status epilepticus (SE) using specific gravimetry and T2 MRI techniques at 6 h, 1 day, 4 days and 7 days after SE. Our results indicate significantly greater tissue edema and T2 MRI changes in AQP4(-/-) compared to AQP4(+/+) mice that peaks at about 1 day after SE (greater in hippocampus relative to cortex). These results have implications for the mechanisms of edema formation and clearance following intense seizure activity.
我们使用比重法和 T2 MRI 技术，在 SE 后 6 h、1 天、4 天和 7 天，研究了水通道蛋白-4（AQP4）在红藻氨酸诱导的癫痫持续状态（SE）后脑水肿发展中的作用。我们的结果表明，与 AQP4(+/+)小鼠相比，AQP4(-/-)小鼠在 SE 后约 1 天出现明显的组织水肿和 T2 MRI 变化（海马相对于皮层更明显）。这些结果对强烈癫痫活动后水肿形成和清除的机制有影响。
