Department of Cardiovascular Medicine, Lahey Clinic, 14 Mall Road, Burlington, Massachusetts 01805, USA.
J Am Coll Cardiol. 2011 Oct 18;58(17):1733-40. doi: 10.1016/j.jacc.2011.07.022.
The changes in left ventricular (LV) structure and geometry that evolve after myocardial injury or overload usually involve chamber dilation and/or hypertrophy. Such architectural remodeling can be classified as eccentric or concentric. Consideration of LV volume, mass, and relative wall thickness (or mass/volume) allows classification of LV remodeling that includes virtually all LV remodeling changes that are seen in health and disease. These various architectural changes generally include the development of LV hypertrophy in a pattern that is closely related to the type of injury or overload, and they are accompanied by differences in cardiac function and hemodynamics. Some patterns of remodeling are associated with adverse outcomes whereas others appear to be adaptive and physiologic without adverse consequences. Considering all patients with LV hypertrophy as a homogenous group is inconsistent with our understanding of the various remodeling patterns that are discussed in this review.
心肌损伤或超负荷后左心室（LV）结构和几何形状的变化通常涉及腔室扩张和/或肥大。这种结构重构可以分为偏心性或同心性。考虑到 LV 容积、质量和相对壁厚度（或质量/容积），可以对 LV 重构进行分类，包括在健康和疾病中观察到的几乎所有 LV 重构变化。这些各种结构变化通常包括与损伤或超负荷类型密切相关的 LV 肥大模式的发展，并且伴随着心脏功能和血液动力学的差异。一些重构模式与不良结局相关，而另一些则似乎是适应性和生理性的，没有不良后果。将所有 LV 肥大患者视为同质组与我们对本综述中讨论的各种重构模式的理解不一致。
