黏菌素能有效杀死胃癌中 ALDH（高）的干细胞样细胞。
Salinomycin can effectively kill ALDH(high) stem-like cells on gastric cancer.
机构信息
Shanghai Key Laboratory of Diagnosis and Treatment for Gastric Cancer, Shanghai Jiao Tong University, School of Medicine, Ruijin er Road, No. 197, 200025 Shanghai, China.
出版信息
Biomed Pharmacother. 2011 Oct;65(7):509-15. doi: 10.1016/j.biopha.2011.06.006. Epub 2011 Aug 27.
Salinomycin is a novel identified cancer stem cells (CSCs) killer. Higher ALDH activity represents CSCs characterization. Here, we screened ALDH activities on several gastric cancer cell lines and divided them into ALDH(high) and ALDH(low) gastric cancer groups. ALDH(high) cancer cells (NCI-N87 and SNU-1) disclosed more CSCs characteristics, such as higher levels of Sox2, Nanog and Nestin, more floating spheroid bodies, more colony formation and more resistance to conventional chemotherapeutic drugs 5-Fu and CDDP, compared to these parameters observed in ALDH(low) cancer cells (P<0.01). Importantly, ALDH(high) cancer cells are relatively sensitive to salinomycin when compared to ALDH(low) cancer cells (P<0.01). Our results confirmed ALDH as functional marker of CSCs population on gastric cancer. Salinomycin might be selective therapy for CSCs fraction, which is resistant to conventional anticancer drugs 5-Fu and CDDP.
黏菌素是一种新型鉴定的癌症干细胞（CSCs）杀手。更高的 ALDH 活性代表 CSCs 的特征。在这里，我们在几种胃癌细胞系上筛选了 ALDH 活性，并将它们分为 ALDH（高）和 ALDH（低）胃癌组。ALDH（高）癌细胞（NCI-N87 和 SNU-1）表现出更多的 CSCs 特征，如更高水平的 Sox2、Nanog 和 Nestin、更多的漂浮球体、更多的集落形成和对常规化疗药物 5-Fu 和 CDDP 的更高抗性，与 ALDH（低）癌细胞中观察到的这些参数相比（P<0.01）。重要的是，与 ALDH（低）癌细胞相比，ALDH（高）癌细胞对黏菌素相对敏感（P<0.01）。我们的结果证实了 ALDH 作为胃癌 CSCs 群体的功能标志物。黏菌素可能是对常规抗癌药物 5-Fu 和 CDDP 耐药的 CSCs 亚群的选择性治疗方法。
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