Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile.
Molecules. 2011 Oct 13;16(10):8614-28. doi: 10.3390/molecules16108614.
New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for basal cytotoxicity on the following human cell lines: Normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellular carcinoma (Hep G2). Several of the new compounds were significantly active as antiulcer agents and showed selective cytotoxicity against AGS cells.
新型二萜基萘醌由土木香酸和拉帕醇缩合而成。这些新衍生物通过 HCl-EtOH 诱导的小鼠胃损伤模型评估为胃保护剂，同时对以下人类细胞系的基础细胞毒性进行评估：正常肺成纤维细胞（MRC-5）、胃上皮腺癌（AGS）和肝癌（Hep G2）。一些新化合物具有显著的抗溃疡活性，并对 AGS 细胞表现出选择性细胞毒性。
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