• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

二萜萘醌衍生物的合成及药理活性。

Synthesis and pharmacological activity of diterpenylnaphthoquinone derivatives.

机构信息

Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile.

出版信息

Molecules. 2011 Oct 13;16(10):8614-28. doi: 10.3390/molecules16108614.

DOI:10.3390/molecules16108614
PMID:21996716
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6264310/
Abstract

New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for basal cytotoxicity on the following human cell lines: Normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellular carcinoma (Hep G2). Several of the new compounds were significantly active as antiulcer agents and showed selective cytotoxicity against AGS cells.

摘要

新型二萜基萘醌由土木香酸和拉帕醇缩合而成。这些新衍生物通过 HCl-EtOH 诱导的小鼠胃损伤模型评估为胃保护剂，同时对以下人类细胞系的基础细胞毒性进行评估：正常肺成纤维细胞（MRC-5）、胃上皮腺癌（AGS）和肝癌（Hep G2）。一些新化合物具有显著的抗溃疡活性，并对 AGS 细胞表现出选择性细胞毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d82/6264310/9e1733f0c2b8/molecules-16-08614-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d82/6264310/62716df2f474/molecules-16-08614-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d82/6264310/bc64e5c364e8/molecules-16-08614-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d82/6264310/9e1733f0c2b8/molecules-16-08614-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d82/6264310/62716df2f474/molecules-16-08614-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d82/6264310/bc64e5c364e8/molecules-16-08614-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d82/6264310/9e1733f0c2b8/molecules-16-08614-g001.jpg

相似文献

1
Synthesis and pharmacological activity of diterpenylnaphthoquinone derivatives.二萜萘醌衍生物的合成及药理活性。
Molecules. 2011 Oct 13;16(10):8614-28. doi: 10.3390/molecules16108614.
2
Synthesis, gastroprotective effect and cytotoxicity of new amino acid diterpene monoamides and diamides.新型氨基酸二萜单酰胺和二酰胺的合成、胃保护作用和细胞毒性。
Molecules. 2010 Oct 21;15(10):7378-94. doi: 10.3390/molecules15107378.
3
Potential gastroprotective effect of novel cyperenoic acid/quinone derivatives in human cell cultures.新型吡喃并喹酮衍生物对人细胞培养物的潜在胃保护作用。
Planta Med. 2012 Nov;78(17):1807-12. doi: 10.1055/s-0032-1315389. Epub 2012 Oct 9.
4
Gastroprotective effect and cytotoxicity of labdeneamides with amino acids.具有氨基酸的劳丹脂酰胺的胃保护作用和细胞毒性。
Planta Med. 2011 Mar;77(4):340-5. doi: 10.1055/s-0030-1250323. Epub 2010 Sep 22.
5
Gastroprotective and ulcer-healing activity of oleanolic acid derivatives: in vitro-in vivo relationships.齐墩果酸衍生物的胃保护和溃疡愈合活性：体内外关系
Life Sci. 2006 Aug 29;79(14):1349-56. doi: 10.1016/j.lfs.2006.03.044. Epub 2006 Apr 26.
6
Gastroprotective effect of barbatusin and 3-beta-hydroxy-3-deoxibarbatusin, quinonoid diterpenes isolated from Plectranthus grandis, in ethanol-induced gastric lesions in mice.从大蓬猪儿菜中分离得到的醌型二萜 Barbatusin 和 3-β-羟基-3-去氧 Barbatusin 对乙醇诱导的小鼠胃损伤的胃保护作用。
J Ethnopharmacol. 2010 Feb 17;127(3):725-30. doi: 10.1016/j.jep.2009.11.031. Epub 2009 Dec 16.
7
Gastroprotective activity of a new semi-synthetic solidagenone derivative in mice.一种新型半合成鼠李素衍生物对小鼠的胃保护活性
J Pharm Pharmacol. 2005 Feb;57(2):265-71. doi: 10.1211/0022357055461.
8
Gastroprotective and ulcer healing effect of ferruginol in mice and rats: assessment of its mechanism of action using in vitro models.铁杉脂素对小鼠和大鼠的胃保护及溃疡愈合作用：利用体外模型评估其作用机制
Life Sci. 2006 Apr 18;78(21):2503-9. doi: 10.1016/j.lfs.2005.10.018. Epub 2005 Nov 23.
9
Cochlospermum regium (Mart. ex Schrank) Pilg.: Evaluation of chemical profile, gastroprotective activity and mechanism of action of hydroethanolic extract of its xylopodium in acute and chronic experimental models.肉实树（Mart. ex Schrank）Pilg.：评价其木栓的水-乙醇提取物的化学特征、胃保护活性和作用机制在急性和慢性实验模型中的应用。
J Ethnopharmacol. 2019 Apr 6;233:101-114. doi: 10.1016/j.jep.2019.01.002. Epub 2019 Jan 3.
10
Gastroprotective and anti-secretory mechanisms of 2-phenylquinoline, an alkaloid isolated from Galipea longiflora.从长距球兰中分离得到的生物碱 2-苯基喹啉的胃保护和抗分泌机制。
Phytomedicine. 2017 Feb 15;25:61-70. doi: 10.1016/j.phymed.2016.12.016. Epub 2016 Dec 24.

引用本文的文献

1
Synthesis, Antiviral and Cytotoxic Activity of Novel Terpenyl Hybrid Molecules Prepared by Click Chemistry.新型萜烯杂化分子的点击化学合成、抗病毒及细胞毒性活性研究。
Molecules. 2018 Jun 3;23(6):1343. doi: 10.3390/molecules23061343.
2
Synthesis and Biological Evaluation of Lipophilic 1,4-Naphthoquinone Derivatives against Human Cancer Cell Lines.亲脂性1,4-萘醌衍生物对人癌细胞系的合成及生物学评价
Molecules. 2015 Jun 30;20(7):11994-2015. doi: 10.3390/molecules200711994.
3
Diterpenylquinone hybrids: synthesis and assessment of gastroprotective mechanisms of action in human cells.

本文引用的文献

1
Next-Generation Antimalarial Drugs: Hybrid Molecules as a New Strategy in Drug Design.下一代抗疟药物：杂合分子作为药物设计的新策略。
Drug Dev Res. 2010 Feb;71(1):20-32. doi: 10.1002/ddr.20345.
2
Synthesis, gastroprotective effect and cytotoxicity of new amino acid diterpene monoamides and diamides.新型氨基酸二萜单酰胺和二酰胺的合成、胃保护作用和细胞毒性。
Molecules. 2010 Oct 21;15(10):7378-94. doi: 10.3390/molecules15107378.
3
Cytotoxic and DNA-topoisomerase effects of lapachol amine derivatives and interactions with DNA.拉帕醇胺衍生物的细胞毒性和DNA拓扑异构酶作用以及与DNA的相互作用
二萜醌类杂合体：在人细胞中对胃保护作用机制的合成与评估。
Molecules. 2013 Sep 10;18(9):11044-66. doi: 10.3390/molecules180911044.
4
Dimeric labdane diterpenes: synthesis and antiproliferative effects.二聚型贝壳杉烷二萜：合成与抗增殖作用。
Molecules. 2013 May 21;18(5):5936-53. doi: 10.3390/molecules18055936.
Braz J Med Biol Res. 2007 Oct;40(10):1399-402. doi: 10.1590/s0100-879x2006005000159. Epub 2007 Jul 31.
4
New cytotoxic diterpenylnaphthohydroquinone derivatives obtained from a natural diterpenoid.从一种天然二萜类化合物中获得的新型细胞毒性二萜基萘氢醌衍生物。
Bioorg Med Chem. 2007 Sep 1;15(17):5760-74. doi: 10.1016/j.bmc.2007.06.005. Epub 2007 Jun 8.
5
Long-term risk of gastric cancer by subsite in operated and unoperated patients hospitalized for peptic ulcer.因消化性溃疡住院的手术和未手术患者按部位划分的胃癌长期风险
Am J Gastroenterol. 2007 Jun;102(6):1185-91. doi: 10.1111/j.1572-0241.2007.01161.x. Epub 2007 Apr 13.
6
Gastroprotective effect and cytotoxicity of terpenes from the Paraguayan crude drug "yagua rova" (Jatropha isabelli).巴拉圭生药“yagua rova”（伊莎贝利麻风树）中萜类化合物的胃保护作用及细胞毒性
J Ethnopharmacol. 2007 May 22;111(3):553-9. doi: 10.1016/j.jep.2007.01.003. Epub 2007 Jan 7.
7
Fragments, network biology and designing multiple ligands.片段、网络生物学与多配体设计
Drug Discov Today. 2007 Feb;12(3-4):156-60. doi: 10.1016/j.drudis.2006.12.006. Epub 2006 Dec 14.
8
Gastroprotective and cytotoxic effect of semisynthetic ferruginol derivatives.半合成铁杉醇衍生物的胃保护和细胞毒性作用
J Pharm Pharmacol. 2007 Feb;59(2):289-300. doi: 10.1211/jpp.59.2.0015.
9
The risk of pancreatic cancer in patients with gastric or duodenal ulcer disease.胃溃疡或十二指肠溃疡疾病患者患胰腺癌的风险。
Int J Cancer. 2007 Jan 15;120(2):368-72. doi: 10.1002/ijc.22123.
10
Synthesis of naphthofuranquinones with activity against Trypanosoma cruzi.具有抗克氏锥虫活性的萘并呋喃醌的合成。
Eur J Med Chem. 2006 Apr;41(4):526-30. doi: 10.1016/j.ejmech.2005.12.006. Epub 2006 Feb 28.