从菊芋中分离得到的两种新环氧甾体。

Two new epoxysteroids from Helianthus tuberosus.

机构信息

Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.

出版信息

Molecules. 2011 Oct 13;16(10):8646-53. doi: 10.3390/molecules16108646.

DOI:10.3390/molecules16108646

PMID:21996718

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6264387/

Abstract

Two new epoxy steroids, 5α,8α-epidioxy-22β,23β-epoxyergosta-6-en-3β-ol (1) and 5α,8α-epidioxy-22α,23α-epoxyergosta-6-en-3β-ol (2), and ten known steroids including (24R)-5α,8α-epidioxyergosta-6-en-3β-ol (3), (22E,24R)-5α,8α-epidioxyergosta-6,22-dien-3β-ol (4), (22E,24R)-5α,8α-epidioxyergosta-6,9(11),22-trien-3β-ol (5), β-sitosterol (6), sitost-5-en-3β-ol acetate (7), 7α-hydroxysitosterol (8), schleicheol 2 (9), (24R)-24-ethyl-5α-cholestane-3β,5α,6β-triol (10), 7α-hydroxystigmasterol (11), and stigmasterol (12) were isolated from Helianthus tuberosus grown in Laizhou salinized land of coastal zone of Bohai Sea, China. The structures of these compounds were unambiguously established by 1D, 2D NMR and mass spectroscopic techniques. The new compounds 1 and 2 exhibited weak antibacterial activity and no antifungal activity.

摘要

两种新的环氧甾体，5α,8α-表二氧代-22β,23β-环氧麦角甾-6-烯-3β-醇（1）和 5α,8α-表二氧代-22α,23α-环氧麦角甾-6-烯-3β-醇（2），以及包括（24R）-5α,8α-表二氧代麦角甾-6-烯-3β-醇（3）、（22E,24R）-5α,8α-表二氧代麦角甾-6,22-二烯-3β-醇（4）、（22E,24R）-5α,8α-表二氧代麦角甾-6,9(11),22-三烯-3β-醇（5）、β-谷甾醇（6）、豆甾-5-烯-3β-醇乙酸酯（7）、7α-羟基谷甾醇（8）、schleicheol 2（9）、（24R）-24-乙基-5α-胆甾烷-3β,5α,6β-三醇（10）、7α-羟基豆甾醇（11）和豆甾醇（12）从中国渤海沿海莱州盐化土地生长的向日葵中分离得到。这些化合物的结构通过 1D、2D NMR 和质谱技术得到明确确定。新化合物 1 和 2 表现出较弱的抗菌活性，没有抗真菌活性。