Ito Yuki, Ramdhan Doni Hikmat, Yanagiba Yukie, Yamagishi Nozomi, Kamijima Michihiro, Nakajima Tamie
Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences, Japan.
Nihon Eiseigaku Zasshi. 2011 Sep;66(4):638-42. doi: 10.1265/jjh.66.638.
Diesel exhaust (DE) is one of the air pollutants in the world, and exposure to DE is an environmental health concern. Most studies amongst the limited number of studies on hepatotoxicity have focused on genotoxicity or mutagenicity. However, DE exposure may cause liver damage because one prospective study suggests that DE exposure is associated with increased mortality due to arteriosclerosis and cirrhosis of the liver. Peroxisome proliferator-activated receptor (PPAR) α plays a role in the regulation of lipid homeostasis and inflammation and thereby may be involved in the progression of atherosclerosis. We investigated whether nanoparticle-rich diesel exhaust (NR-DE) affects the liver and how PPARα is involved in the NR-DE induced effects. We report these results briefly in this minireview. Our results suggest NR-DE-induced hepatic inflammation and dyslipidemia. PPARα may be involved in the development of these disorders.
柴油废气（DE）是全球空气污染物之一，接触DE是一个环境卫生问题。在有限的关于肝毒性的研究中，大多数研究都集中在基因毒性或致突变性上。然而，DE暴露可能会导致肝脏损伤，因为一项前瞻性研究表明，DE暴露与因动脉硬化和肝硬化导致的死亡率增加有关。过氧化物酶体增殖物激活受体（PPAR）α在脂质稳态和炎症调节中起作用，因此可能参与动脉粥样硬化的进展。我们研究了富含纳米颗粒的柴油废气（NR-DE）是否会影响肝脏以及PPARα如何参与NR-DE诱导的效应。我们在这篇简短综述中简要报告这些结果。我们的结果表明NR-DE会引发肝脏炎症和血脂异常。PPARα可能参与这些疾病的发展。
