抗癌药物的双重特性：三十种药物体外抗假丝酵母菌特性的探索性研究。
Dual properties of anticancer agents: an exploratory study on the in vitro anti-Candida properties of thirty drugs.
机构信息
DST-FIST Sponsored School of Life Sciences, SRTM University, Nanded, India.
出版信息
Chemotherapy. 2011;57(5):372-80. doi: 10.1159/000330454. Epub 2011 Oct 11.
BACKGROUND
Anticancer/antineoplastic agents could be a good resource for the discovery of novel antifungal agents and targets since human beings share a common eukaryotic heritage with fungi.
METHODS
Thirty commonly prescribed anticancer drugs belonging to 12 different classes were analyzed for their effects on the growth of Candida albicans. Minimum inhibitory concentrations (MICs) were obtained using standard CLSI-M27 A2 methodology, and minimal fungicidal concentrations (MFCs) were determined via the agar plate method.
RESULTS
Anticancer agents inhibited the growth of C. albicans in a concentration-dependent manner. Nine drugs from different classes were effective at low concentrations (≤50 μg·ml(-1)), while 15 anticancer drugs exhibited MICs of 100 μg·ml(-1). Sixteen out of 30 drugs exerted fungicidal activity in the range of 400-800 μg·ml(-1).
CONCLUSIONS
MICs and MFCs for 30 anticancer drugs were established against C. albicans. Our study highlighted the anti-Candida potential of these drugs, which may give insights to unexplored targets for antifungal chemotherapy.
背景
由于人类与真菌拥有共同的真核生物遗产，抗癌/抗肿瘤药物可能是发现新型抗真菌药物和靶标的良好资源。
方法
分析了 30 种常用的属于 12 个不同类别的抗癌药物对白色念珠菌生长的影响。采用 CLSI-M27 A2 标准方法测定最小抑菌浓度（MIC），采用琼脂平板法测定最小杀菌浓度（MFC）。
结果
抗癌药物以浓度依赖性方式抑制白色念珠菌的生长。9 种来自不同类别的药物在低浓度（≤50μg·ml（-1））时有效，而 15 种抗癌药物的 MIC 值为 100μg·ml（-1）。30 种药物中有 16 种在 400-800μg·ml（-1）的范围内具有杀菌活性。
结论
确定了 30 种抗癌药物对白色念珠菌的 MIC 和 MFC。我们的研究强调了这些药物的抗白色念珠菌潜力，这可能为抗真菌化疗提供了对未知靶点的深入了解。
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