Department of Anthropology, University of South Carolina, SC 29208, USA.
Am J Phys Anthropol. 2011 Dec;146(4):609-18. doi: 10.1002/ajpa.21622. Epub 2011 Oct 14.
Numerous studies have demonstrated significant associations between periodontal disease and many other diseases in living populations, and some studies have shown that individuals with periodontal disease are at elevated risks of mortality. Recent analysis of a medieval skeletal sample from London has also shown that periodontal disease was associated with increased risks of mortality in the past. This study examines whether periodontal disease is associated with periosteal lesions in a skeletal sample from the urban St. Mary Graces cemetery (n = 265) from medieval London. The results reveal a significant association between periodontal disease and periosteal lesions in the St. Mary Graces sample (i.e., individuals with periodontal disease were also likely to have periosteal lesions), and the association between the two is independent of age. The association between the two pathological conditions might reflect underlying reduced immune competence and thus heightened susceptibility to pathogens that cause periodontal disease or periosteal lesions, exposure to an environmental factor, or underlying heightened inflammatory responses.
大量研究表明，牙周病与现存活人口中的许多其他疾病之间存在显著关联，一些研究表明，患有牙周病的个体的死亡率风险会升高。最近对来自伦敦的中世纪骨骼样本的分析也表明，过去牙周病与死亡率升高有关。本研究探讨了牙周病是否与来自中世纪伦敦圣玛丽·格雷丝公墓（n=265）的骨骼样本中的骨膜病变有关。结果表明，在圣玛丽·格雷丝样本中，牙周病与骨膜病变之间存在显著关联（即患有牙周病的个体也可能有骨膜病变），并且这种关联与年龄无关。这两种病理状况之间的关联可能反映了潜在的免疫能力下降，从而导致对引起牙周病或骨膜病变的病原体、环境因素或潜在的炎症反应过度敏感。
