Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Mov Disord. 2012 Mar;27(3):357-63. doi: 10.1002/mds.23967. Epub 2011 Oct 13.
Deep brain stimulation has been used as a means of reducing dyskinesias in various conditions, including Parkinson's disease and dystonia for many years. Recently, owing to the clinical similarities between L-dopa induced dyskinesia and chorea, deep brain stimulation has now been implemented as a novel treatment method in both Huntington's disease and neuroacanthocytosis, and a paucity of case studies exist reporting its efficacy. This review will summarize the case studies of deep brain stimulation in both Huntington's disease and neuroacanthocytosis, and discuss the possible implications and limitations associated with these reports. As both these disorders are often refractory to medication and difficult to treat, deep brain stimulation may be a useful treatment option in the future.
多年来，深部脑刺激已被用作减少各种疾病（包括帕金森病和肌张力障碍）运动障碍的手段。最近，由于左旋多巴诱导的运动障碍和舞蹈病之间的临床相似性，深部脑刺激现已成为亨廷顿病和神经棘红细胞增多症的一种新的治疗方法，并且存在少量报告其疗效的病例研究。本综述将总结深部脑刺激在亨廷顿病和神经棘红细胞增多症中的病例研究，并讨论这些报告相关的可能意义和局限性。由于这两种疾病通常对药物治疗有抵抗力且难以治疗，深部脑刺激可能是未来的一种有用的治疗选择。
