Department of Obstetrics and Gynaecology, University of Calgary, Calgary, Alberta, Canada.
J Perinatol. 2012 Jun;32(6):460-5. doi: 10.1038/jp.2011.133. Epub 2011 Oct 13.
To estimate sensitivity, specificity, positive and negative predictive values (PPV, NPV) of insulin-like growth factor binding protein-1 (phIGFBP-1) test in predicting preterm delivery in women with symptoms of preterm labor. Secondary objectives were to compare test characteristics of the phIGFBP-1 and fetal fibronectin (fFN) tests.
Labor and delivery units in two Calgary hospitals. Subjects were 349 women with suspected labor between 24 and 35 weeks gestational age (GA). Women had cervical phIGFBP-1 test +/- and fFN testing. Sensitivity, specificity, PPV and NPV were estimated. Primary outcome was birth <37 weeks GA.
Sensitivity of phIGFBP-1 test for delivery <37 weeks was 0.39; specificity, 0.76; PPV, 0.24; NPV, 0.86. NPV of phIGFBP-1 did not differ greatly from that of fFN testing (0.88).
NPV did not differ between phIGFBP-1 and fFN for delivery <37 weeks. Neither test improves on pretest probability of delivery <37 weeks, so clinicians must decide whether the use of either test is justified.
评估胰岛素样生长因子结合蛋白-1（phIGFBP-1）检测在预测有早产症状的孕妇早产中的敏感性、特异性、阳性和阴性预测值（PPV、NPV）。次要目标是比较 phIGFBP-1 和胎儿纤维连接蛋白（fFN）检测的试验特征。
卡尔加里两家医院的分娩和产房。受试者为 349 名妊娠 24 至 35 周有早产症状的孕妇。对这些孕妇进行宫颈 phIGFBP-1 检测 +/-和 fFN 检测。估计敏感性、特异性、PPV 和 NPV。主要结局是出生时 <37 周 GA。
phIGFBP-1 检测用于预测 <37 周分娩的敏感性为 0.39；特异性为 0.76；PPV 为 0.24；NPV 为 0.86。phIGFBP-1 的 NPV 与 fFN 检测结果差异不大（0.88）。
phIGFBP-1 和 fFN 检测用于预测 <37 周分娩的 NPV 无差异。两种检测均不能提高 <37 周分娩的预测前概率，因此临床医生必须决定是否有必要使用这两种检测。
