Farooq Osman, Faden Howard S, Cohen Michael E, Ramanathan Murali, Barrett Helen, Farkas Mark K, Langan Thomas J, Yeh E Ann
Women and Children's Hospital of Buffalo, Buffalo, NY, USA.
J Child Neurol. 2012 Apr;27(4):431-8. doi: 10.1177/0883073811417873. Epub 2011 Oct 12.
Little is known about the neurologic complications of the 2009 Influenza-A H1N1 epidemic in children. We present a retrospective analysis of children evaluated at a tertiary children's hospital who tested positive for H1N1 with neurologic complications. A total of 164 children tested positive for H1N1. Thirty-one of these patients (19%) were evaluated and discharged from the emergency department. Thirty-nine (24%) were treated in the intensive care unit, the remaining 94 (57%) were treated in medical in-patient units. Six subjects died (3.7%). Neurologic complications identified included headache, encephalitis, polyneuropathy, seizures, and malignant hyperthermia. The rate of neurologic complications in this cohort of patients who tested positive for H1N1 was 19%. The incidence of serious neurologic complications was 3%, with another 3% of patients who experienced rapid clinical deterioration and subsequently died. Our observation of neurologic complications associated with 2009 influenza-A H1N1 epidemic suggests the need for clinical vigilance during future influenza epidemics.
关于2009年甲型H1N1流感流行在儿童中引发的神经并发症，人们了解甚少。我们对一家三级儿童医院评估的甲型H1N1流感检测呈阳性且伴有神经并发症的儿童进行了回顾性分析。共有164名儿童甲型H1N1流感检测呈阳性。其中31名患者（19%）在急诊科接受评估并出院。39名（24%）在重症监护病房接受治疗，其余94名（57%）在内科住院病房接受治疗。6名患者死亡（3.7%）。确定的神经并发症包括头痛、脑炎、多发性神经病、癫痫发作和恶性高热。在这组甲型H1N1流感检测呈阳性的患者中，神经并发症发生率为19%。严重神经并发症的发生率为3%，另有3%的患者临床病情迅速恶化，随后死亡。我们对与2009年甲型H1N1流感流行相关的神经并发症的观察表明，在未来流感流行期间需要保持临床警惕。
