Peripheral Combination Devices, Abbott Vascular, Santa Clara, California, USA.
J Biomed Mater Res A. 2012 Jan;100(1):120-4. doi: 10.1002/jbm.a.33246. Epub 2011 Oct 14.
The time-dependent local drug delivery from drug-eluting stents (DES) plays a critical role in reducing restenosis in intravascular stenting. To better understand the basic mechanism of drug release for certain polymer-drug-coated DES platforms, a cylindrical diffusion model was applied successfully to quantitatively describe the experimental drug release data of Dynalink-E in vitro and in vivo. The results showed that the profiles of Dynalink-E everolimus release could be controlled by such characteristic parameters as coating thickness and diffusion coefficient. The model could be used to quantitatively characterize the drug release profiles and IVIV correlations.
药物洗脱支架（DES）的时变局部药物释放在减少血管内支架再狭窄方面起着关键作用。为了更好地了解某些聚合物-药物涂层 DES 平台的药物释放基本机制，成功地应用了圆柱形扩散模型来定量描述 Dynalink-E 的体外和体内药物释放数据。结果表明，Dynalink-E 依维莫司释放的曲线可以通过涂层厚度和扩散系数等特征参数来控制。该模型可用于定量描述药物释放曲线和 IVIV 相关性。
