Department of Radiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, MC 3252, Madison, WI 53792-3252, USA.
Radiographics. 2011 Oct;31(6):1651-68. doi: 10.1148/rg.316115516.
A variety of systemic disorders--infections, noninfectious inflammatory diseases, collagen vascular diseases, hereditary diseases, and acquired immune deficiency diseases--may affect both the skin and the lung. The findings in one organ system can help establish the diagnosis or limit the differential diagnosis. Cutaneous manifestations of many conditions (eg, Kaposi sarcoma) precede thoracic manifestations and sometimes have prognostic implications for respiratory disease; in other conditions (eg, organizing pneumonia in polymyositis and dermatomyositis), thoracic manifestations precede cutaneous ones. When skin and thoracic manifestations develop simultaneously, as occurs in the acute form of sarcoidosis known as Löfgren syndrome, the diagnosis is often readily established. Familiarity with the appearances of skin lesions that are commonly associated with systemic lung disease, especially those that are disease specific, may allow the radiologist to pinpoint a diagnosis even when thoracic imaging findings are nonspecific.
多种全身系统疾病——感染、非传染性炎症性疾病、胶原血管疾病、遗传性疾病和获得性免疫缺陷疾病——均可影响皮肤和肺部。一个器官系统的表现有助于确定诊断或限制鉴别诊断。许多疾病（如卡波西肉瘤）的皮肤表现先于肺部表现，有时对肺部疾病的预后有提示意义；在其他疾病中（如皮肌炎和多发性肌炎中的机化性肺炎），肺部表现先于皮肤表现。当皮肤和肺部表现同时发生时，如称为 Löfgren 综合征的结节病的急性形式，诊断通常很容易确立。熟悉与肺部疾病相关的常见皮肤病变的表现，尤其是那些具有疾病特异性的表现，即使肺部影像学表现不典型，放射科医生也可以确定诊断。
