Souers Stroke Institute, Department of Neurology, St Louis University, 1438 S Grand Boulevard, St Louis, MO 63104, USA.
Stroke. 2012 Jan;43(1):262-4. doi: 10.1161/STROKEAHA.111.635664. Epub 2011 Oct 13.
The purpose of this study was to evaluate the mortality rates associated with cerebral venous-sinus thrombosis in a large national sample.
A cohort of patients with cerebral venous-sinus thrombosis was identified from the National Inpatient Sample database for the years 2000 to 2007. According to the International Classification of Diseases, 9th Revision, Clinical Modification codes, cerebral venous-sinus thrombosis is categorized into pyogenic and nonpyogenic groups. Multivariate logistic regression analysis was used to assess covariates associated with hospital mortality.
Among 3488 patients, the overall mortality rate was 4.39%, which was nonsignificantly higher among the pyogenic group (4.55% versus 3.52%; OR, 0.76; 95% CI, 0.47-1.23). In the pyogenic cerebral venous-sinus thrombosis group, hematologic disorders were the most frequent predisposing condition (16.2%); whereas systemic malignancy followed by hematologic disorders were most common in the nonpyogenic group (14.08% and 10.04%, respectively). Predictors of mortality included age, intracerebral hemorrhage as well as the predisposing conditions of hematologic disorders, systemic malignancy, and central nervous system infection.
Compared with arterial stroke, CVST harbors a relatively low mortality rate. Death is determined by age, the presence of intracerebral hemorrhage, and certain predisposing conditions.
本研究旨在评估大型国家样本中与脑静脉窦血栓形成相关的死亡率。
从 2000 年至 2007 年的国家住院患者样本数据库中确定了脑静脉窦血栓形成患者队列。根据国际疾病分类，第 9 版修正临床修订版，脑静脉窦血栓形成分为化脓性和非化脓性两类。采用多变量逻辑回归分析评估与住院死亡率相关的协变量。
在 3488 例患者中，总体死亡率为 4.39%，化脓性组略高（4.55%比 3.52%；OR，0.76；95%CI，0.47-1.23）。在化脓性脑静脉窦血栓形成组中，血液系统疾病是最常见的易患条件（16.2%）；而非化脓性组中，全身性恶性肿瘤和血液系统疾病最常见（分别为 14.08%和 10.04%）。死亡的预测因素包括年龄、脑出血以及血液系统疾病、全身性恶性肿瘤和中枢神经系统感染等易患条件。
与动脉性卒中相比，CVST 的死亡率相对较低。死亡取决于年龄、脑出血以及某些易患条件。
