Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan.
Neurology. 2011 Oct 25;77(17):1605-10. doi: 10.1212/WNL.0b013e3182343354. Epub 2011 Oct 12.
Very few studies have explored the temporal relationship between hypertension and trigeminal neuralgia (TN). The aim of this population-based follow-up study was to investigate whether hypertension is associated with a higher risk of developing TN.
A total of 138,492 persons with at least 2 ambulatory visits with the principal diagnosis of hypertension in 2001 were enrolled in the hypertension group. The nonhypertension group consisted of 276,984 age- and sex-matched, randomly sampled subjects without hypertension. The 3-year TN-free survival rate and the cumulative incidence of TN were calculated using the Kaplan-Meier method. Cox proportional hazard regression was used to estimate the hazard ratio of TN.
In the hypertension group, 121 patients developed TN during follow-up, while, in the nonhypertension group, 167 subjects developed TN. The crude hazard ratio for the hypertension group was 1.52 (95% confidence interval [CI] 1.20-1.92; p = 0.0005), while, after adjustment for demographic characteristics and medical comorbidities, the adjusted hazard ratio was 1.51 (95% CI 1.19-1.90; p = 0.0006).
This study shows a significantly increased risk of developing TN after hypertension. Further studies are needed to elucidate the underlying mechanism of the association between hypertension and TN.
很少有研究探讨高血压与三叉神经痛（TN）之间的时间关系。本基于人群的随访研究旨在探讨高血压是否与更高的 TN 发病风险相关。
共纳入 2001 年至少有 2 次门诊就诊且主要诊断为高血压的 138492 名患者作为高血压组。非高血压组由 276984 名年龄和性别匹配、无高血压的随机抽样对照组成。采用 Kaplan-Meier 法计算 TN 无复发率和 TN 的累积发病率。采用 Cox 比例风险回归估计 TN 的风险比。
在高血压组中，121 例患者在随访期间发生了 TN，而非高血压组中，167 例患者发生了 TN。高血压组的粗风险比为 1.52（95%置信区间 [CI] 1.20-1.92；p = 0.0005），而在调整了人口统计学特征和合并症后，调整后的风险比为 1.51（95% CI 1.19-1.90；p = 0.0006）。
本研究表明高血压后发生 TN 的风险显著增加。需要进一步研究阐明高血压与 TN 之间关联的潜在机制。
