Borbényi Z, Varga G, Bérczi M, Gurzó M
Szent-Györgyi Albert Orvostudományi Egyetem, Szeged.
Orv Hetil. 1990 Jun 10;131(23):1231-6, 1239-40.
Prognostic factors affecting the leukemic transformation were studied in 43 patients with myelodysplastic syndrome (MDS). Acute leukemia developed in 17 cases and it was nonlymphocytic leukemia in every case. No remission was achieved following antileukemic therapy and most of the cases proved to be true drug-resistant leukemia. Initial granulopenia, thrombopenia or anemia alone did not influence the occurrence of leukemic transformation but pancytopenia indicates bad prognosis. According to FAB classification especially refractory anemia with excess of blasts (RAEB) and RAEB in transformation (RAEB-T) were often followed by leukemic transformation. The granulocyte-macrophage progenitor cell (GM-CFC) content of bone marrow were also studied. The GM-CFC content was decreased in each patient. There was no correlation between GM-CFC number and leukemic transformation, the growth-pattern in agar-gel culture, however, turned out to have prognostic importance. Leukemic type of growth, namely always preceded leukemic transformation.
对43例骨髓增生异常综合征（MDS）患者中影响白血病转化的预后因素进行了研究。17例发生急性白血病，均为非淋巴细胞白血病。抗白血病治疗后未获缓解，多数病例被证明是真正的耐药性白血病。单纯初始粒细胞减少、血小板减少或贫血并不影响白血病转化的发生，但全血细胞减少提示预后不良。根据FAB分类，尤其是原始细胞过多的难治性贫血（RAEB）和转化中的RAEB（RAEB-T）常继以白血病转化。还研究了骨髓中粒细胞-巨噬细胞祖细胞（GM-CFC）含量。每位患者的GM-CFC含量均降低。GM-CFC数量与白血病转化之间无相关性，然而，琼脂凝胶培养中的生长模式具有预后重要性。白血病样生长类型，即在白血病转化之前总是出现。
