Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
J Am Chem Soc. 2011 Nov 16;133(45):18130-3. doi: 10.1021/ja208873k. Epub 2011 Oct 20.
A chemo- and stereoselective asymmetric direct cross-aldol reaction between aliphatic aldehydes and α-chloroaldehydes has been developed as a method for the formation of the sole cross-aldol adduct with both enantio- and diastereocontrol, and either anti- or syn-aldol adducts were obtained in good to excellent stereoselectivities by use of proline or a novel axially chiral amino sulfonamide as catalyst.
已开发出一种对映选择性和立体选择性不对称直接交叉羟醛反应，用于形成具有对映和非对映控制的唯一交叉羟醛加合物，并且通过使用脯氨酸或新型轴向手性氨基磺酰胺作为催化剂，可以以良好到优异的立体选择性获得反式或顺式羟醛加合物。
