Laboratory of Antineoplastic Pharmacology, Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy.
Curr Mol Med. 2011 Dec;11(9):726-31. doi: 10.2174/156652411798062368.
Class III β-tubulin (TUBB3) is a prominent mechanism of drug resistance expressed in a variety of solid tumors and particularly in lung and ovarian cancer. In the classical view, TUBB3 expression and drug resistance have been linked, and together they have been associated with a perturbation in microtubule dynamics. In keeping with this observation, TUBB3 was associated with drug resistance only when chemotherapy included a taxane in its chemical composition. In this review, we demonstrate that the classical supposition about TUBB3 is not correct, and that instead TUBB3 expression is linked to drug resistance as a complex survival mechanism activated by microenvironmental conditions such as poor nutrient supply and hypoxia.
III 类 β-微管蛋白（TUBB3）是多种实体瘤中表达的一种显著的耐药机制，特别是在肺癌和卵巢癌中。在经典观点中，TUBB3 的表达与耐药性相关，它们共同与微管动力学的紊乱有关。根据这一观察结果，只有当化疗药物的化学组成中包含紫杉烷类药物时，TUBB3 才与耐药性相关。在这篇综述中，我们证明了关于 TUBB3 的经典假设是不正确的，相反，TUBB3 的表达与耐药性相关，是一种复杂的生存机制，由微环境条件（如营养供应不良和缺氧）激活。
