McCaughan L
Laser Medical Research Foundation, Columbus, Ohio.
Nurs Clin North Am. 1990 Sep;25(3):725-38.
Photodynamic therapy has been shown to provide a reasonable alternative to other treatment modalities for patients with certain cancers, and in some cases may be the preferred treatment. Currently, photodynamic therapy is under FDA-approved clinical investigational trials in the treatment of tumors of the skin, bronchus, esophagus, bladder, head and neck, and of gynecologic and ocular tumors. Activation of a photosensitizer retained in the cancerous cells, by red light emitted from an argon-tunable dye laser system, produces a photochemical reaction that results in the selective destruction of tumor cells. Although the injected sensitizer results in patient photosensitivity lasting 4 to 8 weeks, there have been no reports of permanent side effects. This treatment can be delivered through fiberoptics--interstitially, endoscopically, retrobulbarly, and externally, and in most cases is performed under local anesthesia. Although this is a relatively new method for treatment of cancer, reports show great promise for palliation and potential cure in some cancer patients.
对于某些癌症患者，光动力疗法已被证明是其他治疗方式的合理替代方案，在某些情况下可能是首选治疗方法。目前，光动力疗法正在美国食品药品监督管理局（FDA）批准的临床试验中用于治疗皮肤、支气管、食管、膀胱、头颈部肿瘤以及妇科和眼部肿瘤。通过氩可调染料激光系统发出的红光激活癌细胞中保留的光敏剂，会产生光化学反应，从而导致肿瘤细胞的选择性破坏。虽然注射的光敏剂会使患者产生持续4至8周的光敏感，但尚无永久性副作用的报告。这种治疗可以通过光纤以间质、内镜、球后和外部的方式进行，并且在大多数情况下是在局部麻醉下进行的。虽然这是一种相对较新的癌症治疗方法，但报告显示在缓解某些癌症患者的症状和潜在治愈方面有很大前景。
