Shaver S W, Kadekaro M, Gross P M
Department of Surgery, Queen's University, Kingston, Ontario, Canada.
Peptides. 1990 May-Jun;11(3):557-63. doi: 10.1016/0196-9781(90)90059-e.
Angiotensin infusion increased glucose metabolism in 4 of 7 subdivisions of the rat subfornical organ, the effect being stronger in ventromedial compared to dorsolateral zones across the rostrocaudal axis. [Sar1-Leu8]Angiotensin II attenuated metabolic responses to intravenous angiotensin in all subfornical organ subregions. Brattleboro rats, having high circulating levels of angiotensin, displayed greater rates of glucose metabolism than Long-Evans rats in all subregions, differences that were eliminated by captopril, an inhibitor of angiotensin converting enzyme. The studies reveal focal subfornical organ zones where in vivo metabolic activity corresponds to cytoarchitectonic evidence for topographical processing within this angiotensin-sensitive structure.
血管紧张素输注增加了大鼠穹窿下器7个亚区中4个亚区的葡萄糖代谢，在整个前后轴上，腹内侧区的这种作用比背外侧区更强。[Sar1-Leu8]血管紧张素II减弱了穹窿下器所有亚区对静脉注射血管紧张素的代谢反应。循环血管紧张素水平较高的布拉特洛维大鼠在所有亚区的葡萄糖代谢率均高于朗-埃文斯大鼠，而血管紧张素转换酶抑制剂卡托普利可消除这些差异。这些研究揭示了穹窿下器的局部区域，其体内代谢活动与该血管紧张素敏感结构内地形学处理的细胞构筑学证据相对应。
