School of Chemical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia.
Nat Prod Res. 2012;26(9):850-8. doi: 10.1080/14786419.2010.551770. Epub 2011 Oct 14.
A new sesquiterpenoid, 1α,4β,7β-eudesmanetriol (1), was isolated together with the known compounds 1β,4β,7β-eudesmanetriol (2) and oplopanone (3) from the rhizomes of Homalomena sagittifolia. The structures of these compounds were determined by extensive spectral analyses. The compounds 1 and 2 inhibited growth of Pseudomonas stutzeri with a MIC value of 117 µM when evaluated for antibacterial activity using the minimum concentration assay. Both these compounds showed remarkable activities against acetylcholinesterase enzyme with IC(50) values ranging between 25 and 26 µM. The isolation of these sesquiterpenoids and their biological activities observed in this study support the reported traditional uses of H. sagittifolia for the treatment of microbial related diseases and central nervous system disorders.
从山蒟的根茎中分离得到了一个新的倍半萜，1α,4β,7β-桉叶三醇（1），以及已知的化合物 1β,4β,7β-桉叶三醇（2）和奥普洛酮（3）。这些化合物的结构通过广泛的光谱分析确定。在最小浓度测定法评估抗菌活性时，化合物 1 和 2 对假单胞菌属的生长具有抑制作用，MIC 值为 117µM。这两种化合物对乙酰胆碱酯酶都表现出显著的活性，IC50 值在 25 到 26µM 之间。本研究中分离得到的这些倍半萜类化合物及其生物活性支持了山蒟用于治疗与微生物相关的疾病和中枢神经系统紊乱的传统用途。
