Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven (K.U. Leuven), Minderbroedersstraat 10, B-3000 Leuven, Belgium.
Cytokine Growth Factor Rev. 2011 Oct-Dec;22(5-6):345-58. doi: 10.1016/j.cytogfr.2011.09.002. Epub 2011 Oct 14.
Cancer is a life-threatening disease world-wide and colorectal cancer is the second common cause of cancer mortality. The interaction between tumor cells and stromal cells plays a crucial role in tumor initiation and progression and is partially mediated by chemokines. Chemokines predominantly participate in the chemoattraction of leukocytes to inflammatory sites. Nowadays, it is clear that CXC chemokines and their receptors (CXCR) may also modulate tumor behavior by several important mechanisms: regulation of angiogenesis, activation of a tumor-specific immune response by attracting leukocytes, stimulation of tumor cell proliferation and metastasis. Here, we review the expression and complex roles of CXC chemokines (CXCL1 to CXCL16) and their receptors (CXCR1 to CXCR6) in colorectal cancer. Overall, increased expression levels of CXC chemokines correlate with poor prognosis.
癌症是一种全球性的危及生命的疾病，结直肠癌是癌症死亡的第二大常见原因。肿瘤细胞与基质细胞之间的相互作用在肿瘤的发生和进展中起着至关重要的作用，部分是由趋化因子介导的。趋化因子主要参与白细胞向炎症部位的趋化作用。如今，已经清楚的是，CXC 趋化因子及其受体（CXCR）也可以通过几种重要的机制来调节肿瘤的行为：调节血管生成、通过吸引白细胞激活肿瘤特异性免疫反应、刺激肿瘤细胞增殖和转移。在这里，我们回顾了 CXC 趋化因子（CXCL1 到 CXCL16）及其受体（CXCR1 到 CXCR6）在结直肠癌中的表达和复杂作用。总的来说，CXC 趋化因子表达水平的增加与预后不良相关。
