发现小分子可增强大鼠胎源性神经干细胞中的星形胶质细胞分化。
Discovery of small molecules that enhance astrocyte differentiation in rat fetal neural stem cells.
机构信息
College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2011 Dec 1;21(23):7050-3. doi: 10.1016/j.bmcl.2011.09.099. Epub 2011 Sep 29.
PMID:22001087
Abstract
1,3,4-Oxadiazole derivatives were found to enhance astrocyte differentiation in rat fetal neural stem cells (NSCs). Differentiation activity was assessed by immunocytochemistry and analysis of mRNA expression of astrocyte markers, GFAP and S100. Compounds 7 and 8 showed approximately a two-fold increase in astrocyte differentiation without engagement of neuronal differentiation and detectable cytotoxicity.
摘要
1,3,4-恶二唑衍生物被发现可增强大鼠胎神经干细胞（NSC）中的星形胶质细胞分化。通过免疫细胞化学和星形胶质细胞标志物 GFAP 和 S100 的 mRNA 表达分析来评估分化活性。化合物 7 和 8 显示约两倍的星形胶质细胞分化增强，而没有神经元分化的参与和可检测的细胞毒性。
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