Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Arch Microbiol. 2012 Feb;194(2):141-5. doi: 10.1007/s00203-011-0759-9. Epub 2011 Oct 15.
The protein derived from the Methanocaldococcus jannaschii MJ0458 gene is annotated as a δ-1-pyrroline 5-carboxylate synthetase and is predicted to be related to aspartokinase and uridylate kinase. Analysis of the predicted protein sequence indicated that it is a unique kinase with few similarities to either uridylate or adenylate kinase. Here, we report that the MJ0458 gene product is a second type of archaeal adenylate kinase, AdkB. This enzyme is different from the established archaeal-specific adenylate kinase in both sequence and predicted tertiary structure.
该蛋白质来源于 Methanocaldococcus jannaschii MJ0458 基因，被注释为 δ-1-吡咯啉 5-羧酸合成酶，预测与天冬氨酸激酶和尿苷酸激酶相关。预测蛋白质序列的分析表明，它是一种独特的激酶，与尿苷酸或腺苷酸激酶的相似性很少。在这里，我们报告 MJ0458 基因产物是第二种古菌腺苷酸激酶，AdkB。该酶在序列和预测的三级结构上均与已建立的古菌特异性腺苷酸激酶不同。
