Agha Mohammad M, Glazier Richard H, Moineddin Rahim, Moore Aideen M, Guttmann Astrid
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
Birth Defects Res A Clin Mol Teratol. 2011 Dec;91(12):1011-8. doi: 10.1002/bdra.22857. Epub 2011 Oct 17.
A twofold increase in the prevalence of congenital heart defects (CHDs) has been reported since the early 1970s with higher rates among children from low socioeconomic status (SES). This increase and the observed SES gap are postulated to be reflective of higher ascertainment, especially increased use of ultrasound and echography. The purpose of this study was to examine if trends over time in the prevalence of CHD were the same for high and low SES groups.
Using the child's health number as a unique identifier and through record linkage, children born in Ontario between 1994 and 2007 were followed for the diagnosis of CHD. Using postal codes and census information, SES quintiles were assigned to each child. We used adjusted rates and used multivariate models to compare trends in the prevalence rate among children born in different SES groups.
Children born in low SES areas (23% of all births) had significantly higher rates of CHDs (rate ratio = 1.20; 95% confidence interval [CI] = 1.15-1.24). While prevalence of nonsevere CHDs declined in all SES groups since 2000, severe CHDs, especially atrial septal defects were on the rise during the study period.
It is assumed that increased ascertainment is responsible for observed increase in the prevalence of CHD, especially minor defects. While the trend and pattern over time changed for severe and nonsevere CHDs, the SES gap remained consistent during the study period. Our results indicate that even free and universal access to a health care system does not eliminate the SES gap observed in the prevalence of CHD.
自20世纪70年代初以来,先天性心脏病(CHD)的患病率已报告增加了两倍,社会经济地位(SES)较低的儿童患病率更高。这种增加以及观察到的SES差距被认为反映了更高的确诊率,尤其是超声和回波描记术使用的增加。本研究的目的是检验高SES组和低SES组CHD患病率随时间的趋势是否相同。
以儿童健康编号作为唯一标识符,通过记录链接,对1994年至2007年在安大略省出生的儿童进行CHD诊断随访。利用邮政编码和人口普查信息,为每个儿童分配SES五分位数。我们使用调整后的发病率,并使用多变量模型比较不同SES组出生儿童的患病率趋势。
出生在低SES地区的儿童(占所有出生儿童的23%)CHD发病率显著更高(发病率比=1.20;95%置信区间[CI]=1.15-1.24)。自2000年以来,所有SES组中非严重CHD的患病率均有所下降,但在研究期间,严重CHD,尤其是房间隔缺损呈上升趋势。
据推测,确诊率的提高是观察到的CHD患病率增加的原因,尤其是轻微缺陷。虽然严重和非严重CHD随时间的趋势和模式发生了变化,但在研究期间SES差距保持一致。我们的结果表明,即使免费和普遍获得医疗保健系统也无法消除在CHD患病率中观察到的SES差距。