Ratnaike S, Kilpatrick T, Tress B, Davis S, Kilpatrick C, Byron K, Deam D
Department of Biochemistry, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Ann Clin Biochem. 1990 May;27 ( Pt 3):195-8. doi: 10.1177/000456329002700303.
The Poser criteria for diagnosing multiple sclerosis (MS) includes clinical, paraclinical and laboratory information. We studied the influence of cerebrospinal fluid (CSF) biochemistry results on the categorisation of patients with suspected MS. A retrospective study was made of 138 patients who had CSF samples sent over a 1 year period to the laboratory for examination for oligoclonal bands. Using the Poser criteria, 23 patients were diagnosed as having definite MS and one patient as probable MS. Cerebrospinal fluid biochemistry upgraded the categorisation from probable to definite MS in 16 of these 24 patients (66%). In this study, we found oligoclonal bands to be more sensitive in the diagnosis of MS (96%) than either the concentration of IgG in the CSF (43.5%) or the IgG expressed as a percentage of the total protein in the CSF (71%). We conclude that CSF biochemistry is a valuable investigation in the evaluation of patients with suspected MS.
用于诊断多发性硬化症（MS）的波泽标准包括临床、副临床和实验室信息。我们研究了脑脊液（CSF）生化结果对疑似MS患者分类的影响。对138例在1年期间将CSF样本送检至实验室检测寡克隆带的患者进行了回顾性研究。根据波泽标准，23例患者被诊断为确诊MS，1例患者被诊断为可能MS。在这24例患者中，脑脊液生化结果将16例（66%）患者的分类从可能MS提升为确诊MS。在本研究中，我们发现寡克隆带在MS诊断中的敏感性（96%）高于脑脊液中IgG浓度（43.5%）或脑脊液中IgG占总蛋白的百分比（71%）。我们得出结论，脑脊液生化检查在评估疑似MS患者时是一项有价值的检查。
