Morocutti C, Pozzessere G, Valle E, Mollica M A, Quadrini R, Sanarelli L, Rizzo P A, Amabile G
Istituto di Clinica delle Malattie Nervose e Mentali, Università La Sapienza, Roma.
Riv Neurol. 1987 May-Jun;57(3):175-80.
A group of 30 patients classified on clinical grounds as having definite (N = 16) or probable MS (N = 14) according to McAlpine's criteria, has been studied using multimodal recordings of evoked potentials (visual, auditory, and somatosensory) and examination of the cerebrospinal fluid (CSF) for oligoclonal bands and Link's Index. Evoked potentials examination proved extremely sensitive in discovering asymptomatic lesions of the central nervous system. CSF data, in particular the presence of oligoclonal bands, had a high sensitivity for MS. According to these electrophysiologic and immunologic results, we have reclassified our patients in conformity with the diagnostic criteria proposed by Bartel. The combination of electrophysiological and CSF data, together with common clinical criteria, led to greater diagnostic accuracy, making it possible to reclassify most patients previously considered to have probable MS as having definite MS.
根据麦卡尔平标准，一组30例临床上被分类为患有确诊多发性硬化症（N = 16）或可能患有多发性硬化症（N = 14）的患者，已使用诱发电位（视觉、听觉和躯体感觉）的多模态记录以及对脑脊液（CSF）进行寡克隆带和林克指数检查进行了研究。诱发电位检查在发现中枢神经系统无症状病变方面被证明极其敏感。脑脊液数据，特别是寡克隆带的存在，对多发性硬化症具有很高的敏感性。根据这些电生理和免疫学结果，我们已根据巴特尔提出的诊断标准对患者进行了重新分类。电生理和脑脊液数据与常见临床标准相结合，提高了诊断准确性，使得能够将大多数先前被认为可能患有多发性硬化症的患者重新分类为患有确诊多发性硬化症。
