Fändriks L, Jönson C
Department of Physiology, University of Göteborg, Sweden.
J Intern Med Suppl. 1990;732:103-7. doi: 10.1111/j.1365-2796.1990.tb01480.x.
This report summarizes data concerning the extrinsic neural control of bicarbonate secretion by the gastric and duodenal mucosa. Parasympathetic vagal effects have been studied in experimental animals and in man by means of direct electrical vagal stimulation, sham-feeding procedures and intracerebroventricular peptide injections. The results show that the vagal nerves have a stimulatory effect on gastroduodenal bicarbonate secretion. Furthermore, both conventional nicotinic and muscarinic cholinoceptor, as well as non-cholinergic transmission, mediate the vagal effect. Sympathetic splanchnic nerve effects have been investigated by means of nerve sections, direct electrical stimulation, reflex activation and stereotaxic electrical hypothalamic stimulation. The data show that the splanchnic nerves have a predominantly inhibitory action on gastroduodenal bicarbonate secretion by use of peripheral adrenergic neurones and receptors of the alpha-2 subtype. The role of the adrenal glands is not fully understood. It is concluded that gastroduodenal bicarbonate secretion is under autonomic neural control, mainly in the classical antagonistic fashion; the parasympathetic vagal nerves stimulate bicarbonate output, whereas the sympathetic splanchnic nerves are mainly inhibitory.
本报告总结了有关胃和十二指肠黏膜碳酸氢盐分泌的外在神经控制的数据。通过直接电刺激迷走神经、假饲程序和脑室内注射肽类物质，在实验动物和人体中研究了副交感神经迷走神经的作用。结果表明，迷走神经对胃十二指肠碳酸氢盐分泌有刺激作用。此外，传统的烟碱型和毒蕈碱型胆碱能受体以及非胆碱能传递均介导迷走神经的作用。通过神经切断、直接电刺激、反射激活和立体定向电刺激下丘脑等方法，研究了交感内脏神经的作用。数据表明，内脏神经通过外周α-2亚型肾上腺素能神经元和受体，对胃十二指肠碳酸氢盐分泌主要起抑制作用。肾上腺的作用尚未完全明了。得出的结论是，胃十二指肠碳酸氢盐分泌受自主神经控制，主要以经典的拮抗方式进行；副交感迷走神经刺激碳酸氢盐分泌，而交感内脏神经主要起抑制作用。
