Fukuyama Y, Hayashi M
Eur Neurol. 1979;18(1):38-48. doi: 10.1159/000115052.
2 patients with hypoparathyroidism, one idiopathic and the other pseudoform, were studied by overnight polygraphic recording of the sleep EEG and related activities before and after start of treatment to investigate their sleep EEG patterns and states, with the results as follows. (1) Conspicuous abnormalities were noted in the sleep record, namely, disappearance of humps, spindles and hill waves, emergence of the mitten pattern and rather monotonous delta rhythm bursts. The EEGs, both awake and asleep, showed findings suggestive of a possible disorder of the desynchronizing mechanism of the brain stem. Normal sleep EEG patterns were restored after the serum calcium level had returned to the normal range. (2) In the course of overnight sleep, disturbance in the cyclic changes of sleep EEG pattern and absence of REM sleep were observed. Restoration to the normal course of sleep was achieved following the normalization of serum calcium level. Divalent calcium ion is considered to have intimate bearing upon the mechanism whereby synaptic chemical transmitters are activated. When viewed with reference to the monoamine hypothesis of Jouvet, the disturbance in the course of sleep observed in the present cases, especially the absence of or disturbed REM sleep, is inferred to be related to the hypocalcemia.
对2例甲状旁腺功能减退症患者进行了研究，其中1例为特发性，另1例为假性。在开始治疗前后，通过对睡眠脑电图及相关活动进行夜间多导记录，以研究其睡眠脑电图模式和状态，结果如下。(1)睡眠记录中发现明显异常，即驼峰波、纺锤波和尖波消失，出现手套样图形以及较为单调的δ节律爆发。清醒和睡眠时的脑电图均显示出提示脑干去同步化机制可能存在紊乱的表现。血清钙水平恢复到正常范围后，睡眠脑电图模式恢复正常。(2)在夜间睡眠过程中，观察到睡眠脑电图模式的周期性变化紊乱以及快速眼动睡眠缺失。血清钙水平正常化后，睡眠恢复到正常过程。二价钙离子被认为与突触化学递质激活机制密切相关。参照茹韦的单胺假说来看，本病例中观察到的睡眠过程紊乱，尤其是快速眼动睡眠缺失或紊乱，被推断与低钙血症有关。
