恶性胶质瘤的动脉内化疗：批判性分析
Intra-arterial chemotherapy for malignant gliomas: a critical analysis.
作者信息
Burkhardt J-K, Riina H A, Shin B J, Moliterno J A, Hofstetter C P, Boockvar J A
机构信息
Department of Neurological Surgery, Weill Cornell Brain Tumor Center, Weill Cornell Medical College, New York, [corrected] USA.
出版信息
Interv Neuroradiol. 2011 Sep;17(3):286-95. doi: 10.1177/159101991101700302. Epub 2011 Oct 17.
Abstract
Intra-arterial (IA) chemotherapy for malignant gliomas including glioblastoma multiforme was initiated decades ago, with many preclinical and clinical studies having been performed since then. Although novel endovascular devices and techniques such as microcatheter or balloon assistance have been introduced into clinical practice, the question remains whether IA therapy is safe and superior to other drug delivery modalities such as intravenous (IV) or oral treatment regimens. This review focuses on IA delivery and surveys the available literature to assess the advantages and disadvantages of IA chemotherapy for treatment of malignant gliomas. In addition, we introduce our hypothesis of using IA delivery to selectively target cancer stem cells residing in the perivascular stem cell niche.
摘要
几十年前就开始了针对包括多形性胶质母细胞瘤在内的恶性胶质瘤的动脉内（IA）化疗，自那时起已经进行了许多临床前和临床研究。尽管诸如微导管或球囊辅助等新型血管内装置和技术已被引入临床实践，但IA治疗是否安全且优于其他给药方式（如静脉内（IV）或口服治疗方案）的问题仍然存在。本综述聚焦于IA给药，并调查现有文献以评估IA化疗治疗恶性胶质瘤的优缺点。此外，我们提出了利用IA给药选择性靶向血管周围干细胞龛中癌症干细胞的假说。
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本文引用的文献
1
Generation of neural stem cells: a team approach.神经干细胞的生成：团队协作方法
Neurosurgery. 2010 Dec;67(6):N22-3. doi: 10.1227/01.neu.0000390618.03950.46.
2
Glioblastoma stem-like cells give rise to tumour endothelium.胶质母细胞瘤干细胞可产生肿瘤内皮细胞。
Nature. 2010 Dec 9;468(7325):829-33. doi: 10.1038/nature09624. Epub 2010 Nov 21.
3
Safety and maximum tolerated dose of superselective intraarterial cerebral infusion of bevacizumab after osmotic blood-brain barrier disruption for recurrent malignant glioma. Clinical article.超选择性颅内动脉内注射贝伐单抗治疗复发性恶性脑胶质瘤后脑脊液渗透性血脑屏障破坏的安全性和最大耐受剂量。临床文章。
J Neurosurg. 2011 Mar;114(3):624-32. doi: 10.3171/2010.9.JNS101223. Epub 2010 Oct 22.
4
Tapping an abundant resource: engineering pluripotent stem cells from blood.开发丰富资源：从血液中构建多能干细胞
Neurosurgery. 2010 Oct;67(4):N25. doi: 10.1227/01.neu.0000389740.23932.d1.
5
Understanding the role of tumor stem cells in glioblastoma multiforme: a review article.了解肿瘤干细胞在多形性胶质母细胞瘤中的作用：一篇综述文章。
J Neurooncol. 2011 Jul;103(3):397-408. doi: 10.1007/s11060-010-0406-3. Epub 2010 Sep 18.
6
Intra-arterial Chemotherapy with Carboplatin (CBDCA) and Vepesid (VP16) in Primary Malignant Brain Tumours. Preliminary Findings.原发性恶性脑肿瘤中卡铂（CBDCA）和依托泊苷（VP16）的动脉内化疗。初步研究结果。
Interv Neuroradiol. 1996 Dec 20;2(4):277-81. doi: 10.1177/159101999600200405. Epub 2001 May 15.
7
Intra-arterial therapies for hepatocellular carcinoma: where do we stand?经动脉治疗肝细胞癌：我们处于什么位置？
Ann Surg Oncol. 2010 May;17(5):1234-46. doi: 10.1245/s10434-010-0977-4. Epub 2010 Apr 20.
8
Superselective ophthalmic artery chemotherapy as primary treatment for retinoblastoma (chemosurgery).超选择性眼动脉化疗作为视网膜母细胞瘤（化疗手术）的主要治疗方法。
Ophthalmology. 2010 Aug;117(8):1623-9. doi: 10.1016/j.ophtha.2009.12.030. Epub 2010 Apr 9.
9
Balloon-assisted superselective intra-arterial cerebral infusion of bevacizumab for malignant brainstem glioma. A technical note.球囊辅助超选择性脑动脉内注射贝伐单抗治疗恶性脑干胶质瘤：技术说明
Interv Neuroradiol. 2010 Mar;16(1):71-6. doi: 10.1177/159101991001600109. Epub 2010 Mar 25.
10
Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group.高级别胶质瘤更新后的反应评估标准：神经肿瘤学工作组的反应评估。
J Clin Oncol. 2010 Apr 10;28(11):1963-72. doi: 10.1200/JCO.2009.26.3541. Epub 2010 Mar 15.
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