恶性胶质瘤的动脉内化疗：批判性分析
Intra-arterial chemotherapy for malignant gliomas: a critical analysis.
作者信息
Burkhardt J-K, Riina H A, Shin B J, Moliterno J A, Hofstetter C P, Boockvar J A
机构信息
Department of Neurological Surgery, Weill Cornell Brain Tumor Center, Weill Cornell Medical College, New York, [corrected] USA.
出版信息
Interv Neuroradiol. 2011 Sep;17(3):286-95. doi: 10.1177/159101991101700302. Epub 2011 Oct 17.
Abstract
Intra-arterial (IA) chemotherapy for malignant gliomas including glioblastoma multiforme was initiated decades ago, with many preclinical and clinical studies having been performed since then. Although novel endovascular devices and techniques such as microcatheter or balloon assistance have been introduced into clinical practice, the question remains whether IA therapy is safe and superior to other drug delivery modalities such as intravenous (IV) or oral treatment regimens. This review focuses on IA delivery and surveys the available literature to assess the advantages and disadvantages of IA chemotherapy for treatment of malignant gliomas. In addition, we introduce our hypothesis of using IA delivery to selectively target cancer stem cells residing in the perivascular stem cell niche.
摘要
几十年前就开始了针对包括多形性胶质母细胞瘤在内的恶性胶质瘤的动脉内（IA）化疗，自那时起已经进行了许多临床前和临床研究。尽管诸如微导管或球囊辅助等新型血管内装置和技术已被引入临床实践，但IA治疗是否安全且优于其他给药方式（如静脉内（IV）或口服治疗方案）的问题仍然存在。本综述聚焦于IA给药，并调查现有文献以评估IA化疗治疗恶性胶质瘤的优缺点。此外，我们提出了利用IA给药选择性靶向血管周围干细胞龛中癌症干细胞的假说。
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