树突状细胞：纤维化和硬皮病中的新角色。
Dendritic cells: novel players in fibrosis and scleroderma.
机构信息
Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY 10021, USA.
出版信息
Curr Rheumatol Rep. 2012 Feb;14(1):30-8. doi: 10.1007/s11926-011-0215-5.
Abstract
Dendritic cells are professional antigen-presenting cells that are most studied for their function in mediating T-cell tolerance and T-cell activation. In addition, recent evidence indicates that dendritic cells can regulate the vasculature and function of fibroblast-type cells. The potential contribution of dendritic cells to scleroderma and fibrosis is not well-understood. In this article, we review recent studies as well as describe our own ongoing work that points toward a role for dendritic cells in scleroderma and fibrosis.
摘要
树突状细胞是专业的抗原呈递细胞，其在介导 T 细胞耐受和 T 细胞激活方面的功能研究最多。此外，最近的证据表明，树突状细胞可以调节血管系统和成纤维细胞样细胞的功能。树突状细胞对硬皮病和纤维化的潜在贡献尚未得到很好的理解。在本文中，我们回顾了最近的研究，并描述了我们自己正在进行的工作，这些工作指出了树突状细胞在硬皮病和纤维化中的作用。
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本文引用的文献
1
Coordinated regulation of lymph node vascular-stromal growth first by CD11c+ cells and then by T and B cells.CD11c+ 细胞首先协调调节淋巴结血管基质的生长，然后 T 细胞和 B 细胞进一步调节。
J Immunol. 2011 Dec 1;187(11):5558-67. doi: 10.4049/jimmunol.1101724. Epub 2011 Oct 26.
2
Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β.鼠和人肺成纤维细胞通过整合素 αvβ8 介导的 TGF-β激活调节树突状细胞迁移、气道炎症和纤维化。
J Clin Invest. 2011 Jul;121(7):2863-75. doi: 10.1172/JCI45589. Epub 2011 Jun 6.
3
Fibrocytes: emerging effector cells in chronic inflammation.成纤维细胞：慢性炎症中的新兴效应细胞。
Nat Rev Immunol. 2011 Jun;11(6):427-35. doi: 10.1038/nri2990. Epub 2011 May 20.
4
Management of gut inflammation through the manipulation of intestinal dendritic cells and macrophages?通过操纵肠道树突状细胞和巨噬细胞来控制肠道炎症？
Semin Immunol. 2011 Feb;23(1):58-64. doi: 10.1016/j.smim.2011.01.002. Epub 2011 Feb 2.
5
Renal fibrosis in murine obstructive nephropathy is attenuated by depletion of monocyte lineage, not dendritic cells.在小鼠梗阻性肾病中，通过耗尽单核细胞谱系而不是树突状细胞可减轻肾纤维化。
J Pharmacol Sci. 2010;114(4):464-73. doi: 10.1254/jphs.10246fp. Epub 2010 Nov 26.
6
Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas.微生物刺激可使单核细胞完全分化为表达 DC-SIGN/CD209(+)的树突状细胞，用于免疫 T 细胞区。
Cell. 2010 Oct 29;143(3):416-29. doi: 10.1016/j.cell.2010.09.039.
7
Inflammatory dendritic cells--not basophils--are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen.炎性树突状细胞而非嗜碱性粒细胞对于诱导吸入性屋尘螨变应原的 Th2 免疫应答是必需且充分的。
J Exp Med. 2010 Sep 27;207(10):2097-111. doi: 10.1084/jem.20101563. Epub 2010 Sep 6.
8
The role of dendritic and epithelial cells as master regulators of allergic airway inflammation.树突状细胞和上皮细胞作为过敏性气道炎症的主调控者的作用。
Lancet. 2010 Sep 4;376(9743):835-43. doi: 10.1016/S0140-6736(10)61226-3.
9
Distinct evolution of TLR-mediated dendritic cell cytokine secretion in patients with limited and diffuse cutaneous systemic sclerosis.局限型和弥漫型系统性硬皮病患者 TLR 介导的树突状细胞细胞因子分泌的独特演变。
Ann Rheum Dis. 2010 Aug;69(8):1539-47. doi: 10.1136/ard.2009.128207. Epub 2010 May 24.
10
A role for dendritic cells in bleomycin-induced pulmonary fibrosis in mice?树突状细胞在博来霉素诱导的小鼠肺纤维化中的作用？
Am J Respir Crit Care Med. 2010 Aug 1;182(3):385-95. doi: 10.1164/rccm.200907-1164OC. Epub 2010 Apr 15.
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