Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY 10021, USA.
Curr Rheumatol Rep. 2012 Feb;14(1):30-8. doi: 10.1007/s11926-011-0215-5.
Dendritic cells are professional antigen-presenting cells that are most studied for their function in mediating T-cell tolerance and T-cell activation. In addition, recent evidence indicates that dendritic cells can regulate the vasculature and function of fibroblast-type cells. The potential contribution of dendritic cells to scleroderma and fibrosis is not well-understood. In this article, we review recent studies as well as describe our own ongoing work that points toward a role for dendritic cells in scleroderma and fibrosis.
树突状细胞是专业的抗原呈递细胞，其在介导 T 细胞耐受和 T 细胞激活方面的功能研究最多。此外，最近的证据表明，树突状细胞可以调节血管系统和成纤维细胞样细胞的功能。树突状细胞对硬皮病和纤维化的潜在贡献尚未得到很好的理解。在本文中，我们回顾了最近的研究，并描述了我们自己正在进行的工作，这些工作指出了树突状细胞在硬皮病和纤维化中的作用。
