Liu Yun-Hen, Chu Yen, Wu Yi-Cheng, Chen Tzu-Ping, Lu Ming-Shian, Lu Hung-Yi, Yuan Hsu-Chia, Ko Po-Jen
Chang Gung University, Taoyuan, Taiwan, ROC.
Surg Innov. 2012 Jun;19(2):162-70. doi: 10.1177/1553350611421915. Epub 2011 Oct 16.
The feasibility of using a transoral approach to the thoracic cavity has not yet been measured in humans or animals. The present study aimed to evaluate the feasibility of transoral surgical lung biopsy (TOLB) in 10 canines.
Through an incision over the vestibulum oris, a homemade metal tube was introduced into the thoracic cavity under endoscopic guidance and used as a working channel of surgical lung biopsy. TOLB was performed on the predetermined lung lobe by using an electrocautery loop and endoscopic grasper.
Successful surgical lung biopsy was achieved in 8 of 10 animals in a mean time of 132 minutes (range 130-190 minutes). There were no major intraoperative or postoperative complications, and all animals survived for 2 weeks after surgery. Autopsy showed no evidence of vital structure injury, mediastinitis, or empyema.
TOLB was demonstrated to be safe and feasible in a canine model.
经口进入胸腔的方法在人类或动物中尚未得到验证。本研究旨在评估经口手术肺活检（TOLB）在10只犬中的可行性。
通过口腔前庭切口，在内镜引导下将自制金属管插入胸腔，并用作手术肺活检的工作通道。使用电灼环和内镜抓钳对预定的肺叶进行TOLB。
10只动物中有8只成功进行了手术肺活检，平均时间为132分钟（范围130 - 190分钟）。术中及术后均无严重并发症，所有动物术后存活2周。尸检未发现重要结构损伤、纵隔炎或脓胸的证据。
在犬模型中，TOLB被证明是安全可行的。
