Department of Surgical Oncology, King Hussein Cancer Center, Amman, Jordan.
Ann Surg Oncol. 2012 Apr;19(4):1181-4. doi: 10.1245/s10434-011-2076-6. Epub 2011 Oct 18.
Phyllodes tumors are classified as benign, borderline, and malignant according to a group of histological features. The expression of many biological markers has been explored to discriminate between different grades of phyllodes tumor and to predict their behavior. The immunohistochemical expression of CD10 has been shown to discriminate between benign and other grades of phyllodes tumor but has not been evaluated as a predictor of metastasis. The purpose of this study was to evaluate the usefulness of immunohistochemical staining of stromal CD10 in predicting the likelihood of metastasis in phyllodes tumors.
The expression of CD10 was studied in 43 phyllodes tumors (16 benign, 10 borderline, and 17 malignant) using immunohistochemistry to evaluate whether differences in expression correlated with the presence of, and or, development of distant metastasis.
Metastasis occurred in six malignant phyllodes tumors. The expression of CD10 significantly (P<0.05) correlated with the occurrence of distant metastasis.
The expression of CD10 can be used to predict the occurrence of distant metastasis in phyllodes tumors of the breast.
叶状肿瘤根据一组组织学特征分为良性、交界性和恶性。已经探索了许多生物标志物的表达，以区分不同等级的叶状肿瘤，并预测其行为。CD10 的免疫组织化学表达已被证明可以区分良性和其他等级的叶状肿瘤，但尚未评估其作为转移预测因子的作用。本研究旨在评估叶状肿瘤中基质 CD10 的免疫组织化学染色在预测转移可能性方面的有用性。
使用免疫组织化学方法研究了 43 例叶状肿瘤（16 例良性、10 例交界性和 17 例恶性）中 CD10 的表达，以评估表达差异是否与远处转移的存在或发展相关。
6 例恶性叶状肿瘤发生转移。CD10 的表达与远处转移的发生显著相关（P<0.05）。
CD10 的表达可用于预测乳腺叶状肿瘤远处转移的发生。
