Everitt J I, Richter C B
Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709.
Environ Health Perspect. 1990 Apr;85:239-47. doi: 10.1289/ehp.85-1568352.
The consequences of adventitious infectious agents upon the interpretation of toxicology studies performed in rats and mice are incompletely understood. Several prevalent murine pathogens cause alterations of the respiratory system that can confuse the assessment of chemically induced airway injury. In some instances the pathogenesis of infection with these agents has been relatively well studied in the lower respiratory tract. However, there are few well-controlled studies that have examined the upper respiratory region, which result in interpretive problems for toxicologic pathologists. The conduct and interpretation of both short-term and chronic rodent bioassays can be compromised by both the clinical and subclinical manifestations of infectious diseases. This paper reviews several important infectious diseases of the upper airway of rats and mice and discusses the potential influence of these conditions on the results of toxicology studies.
偶然感染因子对在大鼠和小鼠身上进行的毒理学研究结果解读的影响尚未完全明确。几种常见的鼠类病原体可导致呼吸系统改变，从而混淆对化学诱导气道损伤的评估。在某些情况下，这些病原体感染在小鼠下呼吸道的发病机制已有相对充分的研究。然而，很少有严格对照的研究考察过上呼吸道区域，这给毒理病理学家带来了结果解读方面的问题。传染病的临床和亚临床症状可能会对短期和长期啮齿动物生物测定的实施和结果解读产生不利影响。本文综述了大鼠和小鼠上呼吸道的几种重要传染病，并讨论了这些病症对毒理学研究结果的潜在影响。
