Maronpot R R
National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Environ Health Perspect. 1990 Apr;85:331-52. doi: 10.1289/ehp.85-1568315.
The collected comments and pathologic diagnoses of several pathologists are summarized for 18 cases in which lesions were induced in the upper respiratory tract of rats and mice. Specific neoplastic and nonneoplastic lesions of the nose and trachea are described and discussed, and opinions regarding pathogenesis and biologic significance of the lesions are presented. The anatomic and pathophysiologic complexities of the rodent nose in relation to lesion development following inhalation or systemic exposure to xenobiotics are important considerations in the genesis of pathologic changes in this organ.
总结了几位病理学家对18例在大鼠和小鼠上呼吸道诱发病变的病例所收集的评论和病理诊断。描述并讨论了鼻子和气管的特定肿瘤性和非肿瘤性病变，并提出了关于病变发病机制和生物学意义的观点。啮齿动物鼻子在吸入或全身暴露于外源性物质后与病变发展相关的解剖学和病理生理学复杂性，是该器官病理变化发生过程中的重要考虑因素。
