Department of Health Sciences, University of L'Aquila, L'Aquila, Italy.
Philos Trans A Math Phys Eng Sci. 2011 Nov 28;369(1955):4577-90. doi: 10.1098/rsta.2011.0230.
This article provides a snapshot of muscle near-infrared spectroscopy (NIRS) at the end of 2010 summarizing the recent literature, offering the present status and perspectives of the NIRS instrumentation and methods, describing the main NIRS studies on skeletal muscle physiology, posing open questions and outlining future directions. So far, different NIRS techniques (e.g. continuous-wave (CW) and spatially, time- and frequency-resolved spectroscopy) have been used for measuring muscle oxygenation during exercise. In the last four years, approximately 160 muscle NIRS articles have been published on different physiological aspects (primarily muscle oxygenation and haemodynamics) of several upper- and lower-limb muscle groups investigated by using mainly two-channel CW and spatially resolved spectroscopy commercial instruments. Unfortunately, in only 15 of these studies were the advantages of using multi-channel instruments exploited. There are still several open questions in the application of NIRS in muscle studies: (i) whether NIRS can be used in subjects with a large fat layer; (ii) the contribution of myoglobin desaturation to the NIRS signal during exercise; (iii) the effect of scattering changes during exercise; and (iv) the effect of changes in skin perfusion, particularly during prolonged exercise. Recommendations for instrumentation advancements and future muscle NIRS studies are provided.
本文概述了 2010 年末肌肉近红外光谱 (NIRS) 的最新文献，介绍了目前 NIRS 仪器和方法的现状和展望，描述了骨骼肌生理学的主要 NIRS 研究，提出了一些悬而未决的问题并概述了未来的发展方向。到目前为止，不同的 NIRS 技术（例如连续波 (CW) 和空间、时间和频率分辨光谱）已被用于测量运动期间肌肉的氧合作用。在过去的四年中，已经发表了大约 160 篇关于不同生理方面（主要是肌肉氧合和血液动力学）的肌肉 NIRS 文章，这些研究主要使用双通道 CW 和空间分辨光谱商业仪器对上肢和下肢的几个肌肉群进行了研究。不幸的是，在这些研究中，只有 15 项研究利用了多通道仪器的优势。在肌肉研究中应用 NIRS 仍然存在几个悬而未决的问题：（i）NIRS 是否可用于脂肪层较厚的受试者；（ii）运动期间肌红蛋白去饱和度对 NIRS 信号的贡献；（iii）运动期间散射变化的影响；（iv）皮肤灌注变化的影响，特别是在长时间运动期间。本文还为仪器的改进和未来的肌肉 NIRS 研究提供了建议。
