诱导病毒特异性细胞毒性T淋巴细胞作为开发广泛保护性流感疫苗的基础。
Induction of virus-specific cytotoxic T lymphocytes as a basis for the development of broadly protective influenza vaccines.
作者信息
Hillaire Marine L B, Osterhaus Albert D M E, Rimmelzwaan Guus F
机构信息
Department of Virology, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
出版信息
J Biomed Biotechnol. 2011;2011:939860. doi: 10.1155/2011/939860. Epub 2011 Oct 5.
Abstract
There is considerable interest in the development of broadly protective influenza vaccines because of the continuous emergence of antigenic drift variants of seasonal influenza viruses and the threat posed by the emergence of antigenically distinct pandemic influenza viruses. It has been recognized more than three decades ago that influenza A virus-specific cytotoxic T lymphocytes recognize epitopes located in the relatively conserved proteins like the nucleoprotein and that they cross-react with various subtypes of influenza A viruses. This implies that these CD8+ T lymphocytes may contribute to protective heterosubtypic immunity induced by antecedent influenza A virus infections. In the present paper, we review the evidence for the role of virus-specific CD8+ T lymphocytes in protective immunity against influenza virus infections and discuss vaccination strategies that aim at the induction of cross-reactive virus-specific T-cell responses.
摘要
由于季节性流感病毒抗原漂移变体的不断出现以及抗原性不同的大流行性流感病毒出现所带来的威胁，人们对开发具有广泛保护作用的流感疫苗有着浓厚兴趣。三十多年前就已认识到，甲型流感病毒特异性细胞毒性T淋巴细胞识别位于相对保守蛋白质（如核蛋白）中的表位，并且它们能与甲型流感病毒的各种亚型发生交叉反应。这意味着这些CD8 + T淋巴细胞可能有助于由先前甲型流感病毒感染诱导的保护性异亚型免疫。在本文中，我们综述了病毒特异性CD8 + T淋巴细胞在抗流感病毒感染保护性免疫中作用的证据，并讨论了旨在诱导交叉反应性病毒特异性T细胞应答的疫苗接种策略。
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