Farago A, Nishizuka Y
1st Institute of Biochemistry, Semmelweis University Medical School, Budapest, Hungary.
FEBS Lett. 1990 Aug 1;268(2):350-4. doi: 10.1016/0014-5793(90)81284-u.
Protein kinase C functions as the transducer of a second messenger, diacylglycerol, and is the major receptor for tumour-promoting phorbol esters. The enzyme is a family of proteins with closely but distinct structures and individual enzymological properties. Members of the family are differently distributed in particular cell types and limited intracellular locations from lower organisms to mammalian tissues. The enzyme appears to interact with many signalling pathways, and display functions in the processing and modulation of cellular responses to external stimuli. Presumably, each member of the family plays discrete roles in the control of a variety of membrane functions and activation of gene transcription.
蛋白激酶C作为第二信使二酰基甘油的转导分子，是促肿瘤佛波酯的主要受体。该酶是一类蛋白质家族，具有紧密但不同的结构和各自的酶学特性。从低等生物到哺乳动物组织，该家族成员在特定细胞类型和有限的细胞内位置中分布各异。该酶似乎与许多信号通路相互作用，并在处理和调节细胞对外部刺激的反应中发挥作用。据推测，该家族的每个成员在控制多种膜功能和激活基因转录中发挥着不同的作用。
