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中药心血舒通过保护血管内皮功能的抗动脉粥样硬化和抗缺血作用。

Antiatherogenic and Anti-Ischemic Properties of Traditional Chinese Medicine Xinkeshu via Endothelial Protecting Function.

机构信息

Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, China.

出版信息

Evid Based Complement Alternat Med. 2012;2012:302137. doi: 10.1155/2012/302137. Epub 2011 Oct 10.

DOI:10.1155/2012/302137
PMID:22007259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3191825/
Abstract

Including herbal medicine, complementary and alternative medicine (CAM) is popular worldwide. The traditional Chinese medicine xinkeshu has been widely used to treat coronary heart disease in China. This study was designed to investigate the protective effect and probable mechanism of xinkeshu tablet to atherosclerotic myocardial ischemia rabbit. Rabbits were divided into four groups (n = 12 each) and fed with different diet for 12 weeks: Control (standard diet), Model (high-cholesterol diet), XKS (high-cholesterol diet with 184.8 mg/kg/d xinkeshu), and Atorvastatin (high-cholesterol diet with 5.0 mg/kg/d atorvastatin). Plasma lipoprotein, ECG, endothelium-dependent vessel relaxation, histomorphological study, and expressions of eNOS and VCAM-1 on coronary arteries were assessed. The findings showed that, similar to atorvastatin, xinkeshu presented significant effects on rescuing endothelium-dependent vessel relaxation, inhibiting atherosclerotic progress, preventing myocardial ischemia, and changing eNOS and VCAM-1 expression. However, xinkeshu showed no lipoprotein lowering effect in hypercholesterolemia rabbits. The results of the present study indicated that xinkeshu exerted potent antiatherogenic and anti-ischemic properties on atherosclerotic myocardial ischemia rabbit. An endothelial protecting effect may be involved in the mechanism other than antihyperlipidemic effect.

摘要

包括草药在内，补充和替代医学（CAM）在世界范围内很流行。中药心血舒在中国被广泛用于治疗冠心病。本研究旨在探讨心血舒片对动脉粥样硬化性心肌缺血兔的保护作用及其可能机制。将兔子分为四组（每组 12 只），并给予不同的饮食 12 周：对照组（标准饮食）、模型组（高胆固醇饮食）、XKS 组（高胆固醇饮食加 184.8mg/kg/d 心血舒）和阿托伐他汀组（高胆固醇饮食加 5.0mg/kg/d 阿托伐他汀）。评估血浆脂蛋白、心电图、血管内皮依赖性血管舒张、组织形态学研究以及冠状动脉内皮型一氧化氮合酶（eNOS）和血管细胞黏附分子-1（VCAM-1）的表达。结果表明，与阿托伐他汀相似，心血舒对挽救内皮依赖性血管舒张、抑制动脉粥样硬化进展、预防心肌缺血以及改变 eNOS 和 VCAM-1 的表达具有显著作用。然而，心血舒在高胆固醇血症兔中没有降低脂蛋白的作用。本研究结果表明，心血舒对动脉粥样硬化性心肌缺血兔具有强大的抗动脉粥样硬化和抗缺血作用。内皮保护作用可能与降脂作用以外的机制有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/3191825/2f2722713d32/ECAM2012-302137.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/3191825/45313a541b7f/ECAM2012-302137.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/3191825/b279e4c4292a/ECAM2012-302137.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/3191825/baa2d89e96b0/ECAM2012-302137.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/3191825/5097e1e325f0/ECAM2012-302137.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/3191825/1459de28dda9/ECAM2012-302137.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/3191825/816a3d4fa0ac/ECAM2012-302137.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/3191825/2f2722713d32/ECAM2012-302137.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/3191825/45313a541b7f/ECAM2012-302137.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/3191825/b279e4c4292a/ECAM2012-302137.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/3191825/baa2d89e96b0/ECAM2012-302137.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/3191825/5097e1e325f0/ECAM2012-302137.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/3191825/1459de28dda9/ECAM2012-302137.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/3191825/816a3d4fa0ac/ECAM2012-302137.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/3191825/2f2722713d32/ECAM2012-302137.007.jpg

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