Zhu Chuncheng, Peng Liping, Chen Benchao, He Qun, Wen Qingbo
Hunan University of Traditional Chinese Medicine, Changsha 410007, China.
Zhongguo Zhong Yao Za Zhi. 2011 Jun;36(12):1599-602.
Through the comparison of Xiaoyu ointment and xiaoyu plaster by in vitro transdermal demonstrate, to demonstrate the scientificity and feasibility of reformed formulation.
The improved Franz diffusion cells and in vitro rabbit skin were used in vitro penetration experiment with emodin as an indicator of penetration rate quantitated by HPLC.
The cumulative penetration rate of emodin in Xiaoyu ointment fit the model of Weibull distribution, while the cumulative penetration rate of emodin in Xiaoyu plaster fit the model of Density equation. Take emodin as an index,the transdermal rate in Xiaoyu plaster was 1.93 times as Xiaoyu ointment, and the total penetrated amount was 2.84 times as Xiaoyu ointment. The results showed that the emodin of xiaoyu plaster reserved in the skin were 3.95 times more than the ointment.
The penetration rate, total penetrated amount and the reserves in the skin of Xiaoyu plaster were better than the ointment, and the transdermal dosage form was better than the original form.
通过消瘀膏与消瘀贴剂的体外透皮实验比较，论证改良剂型的科学性与可行性。
采用改良的Franz扩散池和体外兔皮肤进行体外渗透实验，以大黄素为指标，通过高效液相色谱法定量测定渗透速率。
大黄素在消瘀膏中的累积渗透速率符合Weibull分布模型，而在消瘀贴剂中的累积渗透速率符合密度方程模型。以大黄素为指标，消瘀贴剂的透皮速率是消瘀膏的1.93倍，总渗透量是消瘀膏的2.84倍。结果表明，消瘀贴剂中大黄素在皮肤中的留存量比消瘀膏多3.95倍。
消瘀贴剂的渗透速率、总渗透量及在皮肤中的留存量均优于消瘀膏，透皮给药剂型优于原剂型。
