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父母对于膀胱输尿管反流治疗的经历和偏好。

Parental experiences and preferences regarding the treatment of vesicoureteral reflux.

作者信息

Nevéus Tryggve, Brandström Per, Linnér Tina, Jodal Ulf, Hansson Sverker

机构信息

Paediatric Nephrology Unit, Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

出版信息

Scand J Urol Nephrol. 2012 Feb;46(1):26-30. doi: 10.3109/00365599.2011.621144. Epub 2011 Oct 19.

DOI:10.3109/00365599.2011.621144
PMID:22008041
Abstract

OBJECTIVE

Dilating vesicoureteral reflux (VUR) has been linked to febrile urinary tract infection (UTI) and renal scarring. It is unclear, however, whether children with reflux should be treated surgically or medically, or just kept under close surveillance with prompt treatment of UTIs. This lack of evidence makes parental preferences a crucial factor in the choice of therapy. The Swedish Reflux Trial was set up to compare the three treatment alternatives prospectively. This paper focuses on parental experience and satisfaction after completing the trial.

MATERIAL AND METHODS

A group of 203 children aged 12-24 months with reflux grade III or IV were randomly assigned to antibiotic prophylaxis (n = 69), surveillance (n = 68) or endoscopic injection treatment (n = 66) and followed closely for 2 years. Afterwards, the families were interviewed by an investigator not involved in the care of the children about their experience of the study.

RESULTS

Parental satisfaction with the treatment given was high, with 53% scoring 5 and 35% 4 on a five-grade scale, with no difference between the three groups (p = 0.5). Recurrence of febrile UTI or new kidney scarring did not influence parental satisfaction. Even though the satisfaction was high regardless of therapy, parents of children in the prophylaxis group more often than others would have chosen another treatment if given a choice.

CONCLUSIONS

As far as parental satisfaction and preferences are concerned, antibiotic prophylaxis, surveillance and injection treatment are equivalent treatment strategies in children with VUR.

摘要

目的

扩张性膀胱输尿管反流(VUR)与发热性尿路感染(UTI)及肾瘢痕形成有关。然而,尚不清楚反流患儿应接受手术治疗还是药物治疗,或者仅进行密切监测并及时治疗UTI。缺乏证据使得父母的偏好成为治疗选择的关键因素。瑞典反流试验旨在前瞻性地比较这三种治疗方案。本文重点关注试验完成后父母的经历和满意度。

材料与方法

一组203名年龄在12至24个月、反流分级为III级或IV级的儿童被随机分配至抗生素预防组(n = 69)、监测组(n = 68)或内镜注射治疗组(n = 66),并进行为期2年的密切随访。之后,由一名未参与患儿护理的调查员就其研究经历对家庭进行访谈。

结果

父母对所接受治疗的满意度较高,在五级评分中,53%的父母打分为5分,35%打分为4分,三组之间无差异(p = 0.5)。发热性UTI复发或新的肾瘢痕形成并未影响父母的满意度。尽管无论采用何种治疗,满意度都较高,但如果可以选择,预防组患儿的父母比其他组更倾向于选择另一种治疗方法。

结论

就父母的满意度和偏好而言,抗生素预防、监测和注射治疗对于VUR患儿是等效的治疗策略。

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