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1
[Resistant mechanism and treatment strategy of tyrosine kinase inhibitors].酪氨酸激酶抑制剂的耐药机制与治疗策略
Zhongguo Fei Ai Za Zhi. 2011 Oct;14(10):806-10. doi: 10.3779/j.issn.1009-3419.2011.10.07.
2
Clairvoyance or reliable prediction of the future?透视未来还是对未来的可靠预测?
Ann Oncol. 2007 Mar;18(3):407-8. doi: 10.1093/annonc/mdl503.
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Differential responses to erlotinib in epidermal growth factor receptor (EGFR)-mutated lung cancers with acquired resistance to gefitinib carrying the L747S or T790M secondary mutations.表皮生长因子受体(EGFR)突变的肺癌对吉非替尼获得性耐药并携带L747S或T790M继发性突变时,对厄洛替尼的不同反应。
J Clin Oncol. 2008 Mar 1;26(7):1182-4; author reply 1184-6. doi: 10.1200/JCO.2007.14.9039.
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Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway.非小细胞肺癌中表皮生长因子受体通路依赖性获得性表皮生长因子受体酪氨酸激酶抑制剂耐药。
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EGFR mutations in non-small cell lung carcinomas may predict response to gefitinib: extension of an emerging paradigm.非小细胞肺癌中的表皮生长因子受体(EGFR)突变可能预示着对吉非替尼的反应:一种新兴模式的扩展。
Adv Anat Pathol. 2005 Mar;12(2):47-52. doi: 10.1097/01.pap.0000155052.68496.e4.
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Targeted therapies: Tyrosine-kinase inhibitors--new standard for NSCLC therapy.靶向治疗:酪氨酸激酶抑制剂——非小细胞肺癌治疗的新标准。
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Genomic instability as a major mechanism for acquired resistance to EGFR tyrosine kinase inhibitors in cancer.基因组不稳定作为癌症中获得性EGFR酪氨酸激酶抑制剂耐药的主要机制。
Protein Cell. 2022 Feb;13(2):82-89. doi: 10.1007/s13238-021-00855-6. Epub 2021 Jul 28.
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[A case report of patient with advanced non-small cell lung cancer by five times EGFR-TKIs therapy].1例晚期非小细胞肺癌患者接受5次表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKIs)治疗的病例报告
Zhongguo Fei Ai Za Zhi. 2013 Jun;16(6):330-2. doi: 10.3779/j.issn.1009-3419.2013.06.11.
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Personalized medicine and inhibition of EGFR signaling in lung cancer.肺癌中的个性化医疗与表皮生长因子受体信号传导抑制
N Engl J Med. 2009 Sep 3;361(10):1018-20. doi: 10.1056/NEJMe0905763. Epub 2009 Aug 19.
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Time for molecularly targeted maintenance therapy for non-small-cell lung cancer?非小细胞肺癌分子靶向维持治疗的时机到了吗?
Lancet Oncol. 2010 Jun;11(6):500-1. doi: 10.1016/S1470-2045(10)70120-0. Epub 2010 May 20.

本文引用的文献

1
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study.厄洛替尼对比化疗用于治疗晚期 EGFR 突变阳性非小细胞肺癌患者的一线治疗(OPTIMAL、CTONG-0802):一项多中心、开放标签、随机、III 期研究。
Lancet Oncol. 2011 Aug;12(8):735-42. doi: 10.1016/S1470-2045(11)70184-X. Epub 2011 Jul 23.
2
Dual epidermal growth factor receptor (EGFR)/insulin-like growth factor-1 receptor (IGF-1R) inhibitor: a novel approach for overcoming resistance in anticancer treatment.双重表皮生长因子受体(EGFR)/胰岛素样生长因子-1 受体(IGF-1R)抑制剂:克服抗癌治疗耐药性的新方法。
Eur J Pharmacol. 2011 Sep 30;667(1-3):56-65. doi: 10.1016/j.ejphar.2011.04.066. Epub 2011 May 30.
3
Expression of selected gene for acquired drug resistance to EGFR-TKI in lung adenocarcinoma.肺腺癌中获得性 EGFR-TKI 耐药相关基因的表达。
Lung Cancer. 2011 Sep;73(3):361-5. doi: 10.1016/j.lungcan.2011.01.008. Epub 2011 Feb 18.
4
Duration of prior gefitinib treatment predicts survival potential in patients with lung adenocarcinoma receiving subsequent erlotinib.先前接受吉非替尼治疗的时间可预测接受后续厄洛替尼治疗的肺腺癌患者的生存潜力。
Lung Cancer. 2011 Aug;73(2):211-6. doi: 10.1016/j.lungcan.2010.12.014. Epub 2011 Jan 26.
5
EGFR and EML4-ALK gene mutations in NSCLC: a case report of erlotinib-resistant patient with both concomitant mutations.非小细胞肺癌中 EGFR 和 EML4-ALK 基因突变:一例同时存在这两种突变的厄洛替尼耐药患者
Lung Cancer. 2011 Feb;71(2):241-3. doi: 10.1016/j.lungcan.2010.11.014. Epub 2010 Dec 18.
6
Clinical and molecular evidences of epithelial to mesenchymal transition in acquired resistance to EGFR-TKIs.获得性 EGFR-TKIs 耐药中上皮间质转化的临床和分子证据。
Lung Cancer. 2011 Aug;73(2):176-82. doi: 10.1016/j.lungcan.2010.11.011. Epub 2010 Dec 17.
7
Activating and resistance mutations of the epidermal growth factor receptor (EGFR) gene and non-small cell lung cancer: a clinical reality.表皮生长因子受体 (EGFR) 基因的激活和耐药突变与非小细胞肺癌:临床现实。
Arch Bronconeumol. 2011 Feb;47(2):103-5. doi: 10.1016/j.arbres.2010.06.013. Epub 2010 Aug 1.
8
Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression.EML4 和 ALK 的融合与缺乏 EGFR 和 KRAS 突变的肺腺癌的发展相关,并与 ALK 表达相关。
Mol Cancer. 2010 Jul 13;9:188. doi: 10.1186/1476-4598-9-188.
9
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR.吉非替尼或化疗用于治疗具有突变型 EGFR 的非小细胞肺癌。
N Engl J Med. 2010 Jun 24;362(25):2380-8. doi: 10.1056/NEJMoa0909530.
10
A multicenter phase II study to evaluate the efficacy and safety of gefitinib as first-line treatment for Korean patients with advanced pulmonary adenocarcinoma harboring EGFR mutations.一项多中心 II 期研究,旨在评估吉非替尼作为携带 EGFR 突变的晚期肺腺癌韩国患者一线治疗的疗效和安全性。
Lung Cancer. 2011 Jan;71(1):65-9. doi: 10.1016/j.lungcan.2010.04.005.

[Resistant mechanism and treatment strategy of tyrosine kinase inhibitors].

作者信息

Qiao Jianbing, Chen Wenping

机构信息

Department of Medical Respiration, Nanjing Chest Hospital, China.

出版信息

Zhongguo Fei Ai Za Zhi. 2011 Oct;14(10):806-10. doi: 10.3779/j.issn.1009-3419.2011.10.07.

DOI:10.3779/j.issn.1009-3419.2011.10.07
PMID:22008111
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5999947/
Abstract
摘要