Kou Yu-hui, Yin Xiao-feng, Zhang Pei-xun, Jiang Bao-guo
Department of Trauma and Orthopeadics, Peking University People's Hospital, Beijing 100044, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2011 Oct 18;43(5):647-51.
The peripheral nerve injury is a common injury in clinical practice. For centuries, traditional epineurial and perineurial suture techniques have been used to repair nerve transection after peripheral nerve injuries. As there are several types of nerve fibers in neural stump, accurate and effective regeneration of the fibers is limited. The outcome of repairing nerve injury has little improvement till now. Meanwhile , the selective regeneration of peripheral nerve fibers has been gradually confirmed by researchers. The limitation of traditional epineurial and perineurial suture techniques and the phenomenon of selective regeneration of nerve fibers had inspired us with the creative idea: the small-gap bridging suture techniques, which might take the place of the conventional epineurial and perineurial suture methods. We had made a series of detailed studies about this new method, devised a simple and reliable suture method and established an animal model of small-gap bridging suture technique. By observing peripheral nerve regeneration effect of nerve suture with small gap bridging by different gap lengths, we found that the optimal gap was between 1 to 3 mm, developed an artificial conduit with good biocompatibility and gradually applied this new conduit to mammals and primate animal experiments and clinical trials. All the studies obtained reliable results, which confirmed that the small-gap bridging suture was suitable to replace the traditional epineurium suture repairing the peripheral nerve injury. In 2010, this series of research gained the First Prize of Outstanding Scientific Achievement Award by the Ministry of Education.
周围神经损伤是临床实践中常见的损伤。几个世纪以来，传统的神经外膜和束膜缝合技术一直被用于修复周围神经损伤后的神经横断。由于神经残端存在多种类型的神经纤维，纤维的准确有效再生受到限制。迄今为止，神经损伤修复的效果改善甚微。与此同时，周围神经纤维的选择性再生已逐渐得到研究人员的证实。传统神经外膜和束膜缝合技术的局限性以及神经纤维选择性再生的现象启发我们萌生了一个创新想法：小间隙桥接缝合技术，它可能会取代传统的神经外膜和束膜缝合方法。我们对这种新方法进行了一系列详细研究，设计了一种简单可靠的缝合方法，并建立了小间隙桥接缝合技术的动物模型。通过观察不同间隙长度的小间隙桥接神经缝合的周围神经再生效果，我们发现最佳间隙为1至3毫米，研制出了具有良好生物相容性的人工导管，并逐渐将这种新导管应用于哺乳动物、灵长类动物实验及临床试验。所有研究均取得了可靠结果，证实了小间隙桥接缝合适用于取代传统神经外膜缝合来修复周围神经损伤。2010年，这一系列研究获得了教育部优秀科学成果奖一等奖。
