Margolis K L, Nichol K L, Poland G A, Pluhar R E
Hennepin County Medical Center, Minneapolis, MN 55415.
JAMA. 1990 Sep 5;264(9):1139-41.
Concern about side effects constitutes a major deterrent to patient compliance with influenza vaccination, yet there is a paucity of data about the occurrence of adverse reactions in the population targeted for immunization. We conducted a randomized, double-blind, crossover trial to compare the frequency of adverse reactions following administration of 1988-1989 trivalent split-antigen influenza vaccine and saline placebo. Outpatient veterans 65 years of age or over (n = 336) were recruited by mail and were randomly assigned to receive vaccine followed 2 weeks later by placebo injection or placebo followed 2 weeks later by vaccine. There was no significant difference between influenza vaccine and placebo with respect ot the proportion of subjects reporting disability or systemic symptoms.
对副作用的担忧是患者依从流感疫苗接种的主要阻碍因素，然而，针对免疫接种人群中不良反应发生情况的数据却很匮乏。我们进行了一项随机、双盲、交叉试验，以比较1988 - 1989年三价裂解抗原流感疫苗和生理盐水安慰剂接种后不良反应的发生频率。通过邮件招募了65岁及以上的门诊退伍军人（n = 336），并将他们随机分配为先接种疫苗，2周后注射安慰剂，或者先注射安慰剂，2周后接种疫苗。在报告有残疾或全身症状的受试者比例方面，流感疫苗和安慰剂之间没有显著差异。
