Wangoo A, Ganguly N K, Mahajan R C
Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Jpn J Exp Med. 1990 Apr;60(2):45-50.
A comparative study of specific and non-specific immunosuppression has been carried out in acute and chronic Plasmodium berghei infected mice in an in vivo system. In our previous studies, immunosuppression during acute P. berghei infection was attributed to T lymphocytes when we studied modulation of blastogenic response of lymphocytes in an in vitro system. In the present study, delayed type hypersensitivity (DTH) was evident from the homing of radiolabelled bone marrow cells into the delayed lesions of antigen challenged foot pads during chronic infection. This response was suppressed during acute infection especially in early stages. A greater concentration of bone marrow cells in the liver and spleen occurred during chronic infection in comparison with acute infection. When radiolabelled bone marrow cells from infected mice were injected into the normal mice previously given malaria antigen in foot pads, no significant change in homing pattern in liver, spleen or foot pads was observed. Contact sensitivity to picryl chloride was suppressed during acute infection, but was intact during chronic infection. Since these responses are mediated by T lymphocytes, significance of these responses is discussed.
在体内系统中，对感染伯氏疟原虫的急性和慢性小鼠进行了特异性和非特异性免疫抑制的比较研究。在我们之前的研究中，当我们在体外系统中研究淋巴细胞的增殖反应调节时，急性伯氏疟原虫感染期间的免疫抑制归因于T淋巴细胞。在本研究中，慢性感染期间放射性标记的骨髓细胞归巢到抗原攻击的脚垫延迟病变中，延迟型超敏反应（DTH）很明显。这种反应在急性感染期间尤其是早期受到抑制。与急性感染相比，慢性感染期间肝脏和脾脏中的骨髓细胞浓度更高。当将来自感染小鼠的放射性标记骨髓细胞注射到先前在脚垫中给予疟疾抗原的正常小鼠中时，在肝脏、脾脏或脚垫中的归巢模式没有观察到显著变化。急性感染期间对苦味酸氯的接触敏感性受到抑制，但慢性感染期间保持完整。由于这些反应是由T淋巴细胞介导的，因此讨论了这些反应的意义。
