Department of Nuclear Medicine, Kanazawa University Hospital, Kanazawa, Japan.
Eur J Nucl Med Mol Imaging. 2012 Jan;39(1):113-9. doi: 10.1007/s00259-011-1963-1. Epub 2011 Oct 19.
This study was performed to demonstrate that the results obtained with a calibration phantom could be used as a tool for standardizing measurement of heart to mediastinum (H/M) ratio in cardiac metaiodobenzylguanidine (MIBG) imaging.
Images of the phantom containing (123)I-MIBG were acquired on the cameras in 10 hospitals (11 camera types) to determine the relationship between H/M ratios using different collimators: low-energy (LE) and medium-energy (ME)/low-medium-energy (LME) collimators. The effect of standardization on the ME-comparable H/M ratio was examined in two settings: a Japanese standard MIBG database (n = 62) and multicentre studies (n = 49). In a multicentre study, probable Alzheimer's disease (AD, n = 18) and probable dementia with Lewy bodies (DLB, n = 31) were studied and standardized by the calibration phantom method.
Linear regression equations between LE and ME collimators were obtained for the phantom study in all institutions. When the H/M ratio with an LE collimator was corrected based upon the calibration phantom, the corrected values were comparable to those obtained using ME collimators. The standard database also exhibited a normal distribution after standardization as determined by skewness and goodness-of-fit test. A mixture of the populations by LE and ME collimators showed significant separation of AD and DLB groups (F ratio = 24.9 for the late H/M), but the corrected values resulted in higher F ratios for both early and late H/M (F ratio = 34.9 for the late H/M).
Standardization of H/M ratios by the heart-chest calibration phantom method is feasible among different collimator types. This method could be practically used for multicentre comparison of H/M ratios.
本研究旨在证明使用校准体模获得的结果可作为一种工具，用于标准化心脏-纵隔（H/M）比值在心脏间碘苄胍（MIBG）成像中的测量。
在 10 家医院（11 种相机类型）的相机上获取含有（123）I-MIBG 的体模图像，以确定使用不同准直器的 H/M 比值之间的关系：低能（LE）和中能/低-中能（LME）准直器。在两种设置中检查了标准化对 ME 可比 H/M 比值的影响：日本标准 MIBG 数据库（n=62）和多中心研究（n=49）。在多中心研究中，研究了可能的阿尔茨海默病（AD，n=18）和可能的路易体痴呆（DLB，n=31），并使用校准体模方法进行了标准化。
在所有机构的体模研究中，均获得了 LE 和 ME 准直器之间的线性回归方程。当使用 LE 准直器的 H/M 比值根据校准体模进行校正时，校正值与使用 ME 准直器获得的值相当。通过偏度和拟合优度检验，标准化后的标准数据库也表现出正态分布。使用 LE 和 ME 准直器的混合人群显示 AD 和 DLB 组之间存在显著分离（晚期 H/M 的 F 比为 24.9），但校正值导致早期和晚期 H/M 的 F 比更高（晚期 H/M 的 F 比为 34.9）。
使用心脏-胸部校准体模方法对 H/M 比值进行标准化在不同准直器类型之间是可行的。这种方法可实际用于 H/M 比值的多中心比较。
