骨形态发生蛋白 7 在骨折不愈合中的应用。
The use of bone morphogenetic protein 7 in fracture non-unions.
机构信息
Department of Trauma and Orthopaedics, St. Vincent's University Hospital, Elm Park, Dublin, Ireland.
出版信息
Orthop Surg. 2011 Feb;3(1):40-4. doi: 10.1111/j.1757-7861.2010.00119.x.
Abstract
OBJECTIVE
To assess the rate of clinical and radiological union with the use of bone morphogenetic protein 7 (BMP-7) in a range of fractures.
METHODS
This case series retrospectively reviews a series of 16 fracture non-unions in 13 patients. These patients were treated with the commercially available BMP-7. Time to radiological and clinical union was assessed by serial out-patient follow-up.
RESULTS
At nine months post-surgery in which BMP-7 was added, 12 of 16 non-unions had achieved clinical and radiographic union. Three patients required repeat grafting. The mean time to union was 5.1 ± 1.6 months after the application of BMP-7.
CONCLUSION
The use of the osteo-inductive agent, BMP-7 results in good clinical and radiological outcomes which are not restricted to tibial non-unions.
摘要
目的
评估在多种骨折中使用骨形成蛋白 7（BMP-7）的临床和影像学愈合率。
方法
本病例系列回顾性分析了 13 名患者的 16 例骨折不愈合。这些患者使用市售的 BMP-7 进行治疗。通过门诊随访评估影像学和临床愈合的时间。
结果
在 BMP-7 加入后的 9 个月，16 例骨折不愈合中有 12 例达到了临床和影像学愈合。3 名患者需要再次植骨。BMP-7 应用后，平均愈合时间为 5.1±1.6 个月。
结论
使用成骨诱导剂 BMP-7 可获得良好的临床和影像学结果，不仅限于胫骨骨折不愈合。
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