Department of Orthopaedic Surgery, University of Connecticut Health Center, School of Medicine, Farmington, CT 06030, USA.
Adv Drug Deliv Rev. 2012 Sep;64(12):1277-91. doi: 10.1016/j.addr.2012.03.014. Epub 2012 Apr 2.
Over the past several decades, recombinant human bone morphogenetic proteins (rhBMPs) have been the most extensively studied and widely used osteoinductive agents for clinical bone repair. Since rhBMP-2 and rhBMP-7 were cleared by the U.S. Food and Drug Administration for certain clinical uses, millions of patients worldwide have been treated with rhBMPs for various musculoskeletal disorders. Current clinical applications include treatment of long bone fracture non-unions, spinal surgeries, and oral maxillofacial surgeries. Considering the growing number of recent publications related to clincal research of rhBMPs, there exists enormous promise for these proteins to be used in bone regenerative medicine. The authors take this opportunity to review the rhBMP literature paying specific attention to the current applications of rhBMPs in bone repair and spine surgery. The prospective future of rhBMPs delivered in combination with tissue engineered scaffolds is also reviewed.
在过去的几十年中，重组人骨形态发生蛋白（rhBMPs）是研究最广泛、应用最广泛的骨诱导剂，用于临床骨修复。自 rhBMP-2 和 rhBMP-7 被美国食品和药物管理局批准用于某些临床用途以来，全球已有数百万患者接受 rhBMP 治疗各种肌肉骨骼疾病。目前的临床应用包括治疗长骨骨折不愈合、脊柱手术和口腔颌面手术。鉴于与 rhBMP 临床研究相关的大量近期出版物，这些蛋白在骨再生医学中的应用前景广阔。作者借此机会回顾 rhBMP 文献，特别关注 rhBMP 在骨修复和脊柱手术中的当前应用。还回顾了与组织工程支架联合使用的 rhBMP 的未来前景。
